Dynamic crosstalk between amino acid metabolism and cancer drug efficacy: From mechanisms to therapeutic opportunities.

Mengyi Zhu, Changping Wang, Dianwen Song

Abstract readReview

In one paragraph

Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Estrogen deprivation induces hepatic inflammation, Indoleamine-2,3-dioxygenase 1, tryptophan catabolism, and plasma cholesterol.Scientific reports · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mengyi ZhuSchool of Science and Engineering, University of Shanghai Science and Technology, Shanghai 200093, China.

Changping WangDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Dianwen SongSchool of Science and Engineering, University of Shanghai Science and Technology, Shanghai 200093, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer, driven by genomic instability, is profoundly influenced by DNA damage and repair mechanisms. Double-strand breaks (DSBs), repaired via homologous recombination (HR), and non-homologous end joining (NHEJ), are critical for genomic integrity. Defects in DNA damage repair (DDR) pathways, caused by impaired repair mechanisms or mutations in DDR-related proteins, increase cancer risk and therapy resistance. Recent studies highlight amino acid metabolism as a key regulator of DDR, influencing redox balance, energy metabolism, and protein synthesis, which directly impact DNA repair efficiency. This review explores the interplay between DDR, amino acid metabolism, and nanomedicine, emphasizing metabolic reprogramming to enhance genotoxic therapies. By integrating cancer metabolism and precision medicine, we propose targeting amino acid pathways to improve DNA repair and develop next-generation nanomedicine, bridging basic research, and clinical applications for advanced cancer therapy.

Indexed as

Biological sciencesCancer systems biologyHealth sciencesMedical specialtyMedicineNatural sciencesOncologySystems biology

Identifiers

PMID40625405

DOI10.1016/j.isci.2025.112405

PMCPMC12230337

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.