Evidence map›Paper›PMID 40625368›Full record

ArticleJournal of extracellular biology2025

High-Sensitivity Detection of Urinary Extracellular Vesicles With Upconverting Nanoparticle-Based Lateral Flow Immunoassay.

Md Khirul Islam, Imran Mahmud, Klinton Ali, Teppo Salminen, Pekka Taimen, Peter J Boström, Janne Leivo, Urpo Lamminmäki, Iida Martiskainen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Md Khirul IslamBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.ORCID https://orcid.org/0000-0001-8963-1965
Imran MahmudBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.
Klinton AliBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.
Teppo SalminenUniogen Oy Turku Finland.
Pekka TaimenInFLAMES Research Flagship University of Turku Turku Finland.
Peter J BoströmDepartment of Urology Turku University Hospital and University of Turku Turku Finland.
Janne LeivoBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.
Urpo LamminmäkiBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.
Iida MartiskainenBiotechnology Division, Department of Life Technologies and FICAN West Cancer Centre University of Turku Turku Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary extracellular vesicles (uEVs) are well-known to express tetraspanin family membrane proteins abundantly on their surface. In this study, we aimed to develop an upconverting nanoparticle (UCNP)-based lateral flow immunoassay (UCNP-LFIA) designed for the rapid and high-sensitivity detection of CD63-positive uEVs for direct urinalysis. The assay utilizes UCNPs reporter to detect low concentrations of EVs. Minimally processed uEV samples from bladder cancer (BlCa) (

Indexed as

bladder cancerlateral flow assayrapid testtetraspanin CD63upconversion luminescenceurinary EVs

Identifiers

PMID40625368
PMCPMC12229717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.