ArticleFrontiers in medicine2025
Association between sarcopenic obesity and cardiovascular diseases: the role of systemic inflammation indices.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Evaluation of Sarcopenic Obesity in Patients with MASLD.Medical sciences (Basel, Switzerland) · 2026Article
- Systemic inflammatory indices SIRI, AISI, and PWR are associated with sarcopenic obesity in middle-aged and older chinese adults: a cross-sectional study.Nutrition & metabolism · 2026Article
- Development and validation of a nomogram for predicting pulmonary embolism recurrence using muscle and fat parameters.Scientific reports · 2026Article
- Evaluation of novel inflammatory biomarkers in overweight, obese, and morbidly obese children: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Article
- Research Progress on the Association Between Sarcopenic Obesity and Atherosclerosis: Current Status and Challenges.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Background: Research on the relationship between sarcopenic obesity (SO) and multiple cardiovascular diseases is limited, and the regulatory roles of the Aggregate Index of Systemic Inflammation (AISI) and Systemic Inflammation Response Index (SIRI) remain underexplored. Methods: This retrospective observational study included participants aged ≥50 years who underwent routine health examinations between January 1 and December 31, 2024. SO was defined as a low skeletal muscle mass-to-weight ratio (< 33.9% in females, <39.3% in males) and high visceral fat area (≥100 cm Results: This cross-sectional study included 1,010 participants aged ≥50 years. SO was significantly associated with endothelial dysfunction, arterial stiffness, degenerative heart valve disease, and carotid atherosclerosis, with odds ratios (95% confidence intervals) of 1.575 (1.017, 2.441), 1.382 (1.050, 1.818), 1.664 (1.033, 2.681), and 1.430 (1.022, 2.001), respectively. The Johnson-Neyman test identified AISI = 133.48 and SIRI = 0.58 as critical points for significant associations. Conclusion: SO is independently associated with increased cardiovascular disease risk. AISI and SIRI serve as biomarkers for risk stratification, highlighting the need for targeted management to improve cardiovascular outcomes in patients with SO.
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