Evidence map›Paper›PMID 40625241›Full record

SynthesisCNS neuroscience & therapeutics2025

A Meta-Analysis and Systematic Review of the Effects of Sensory Modulation Treatments for Neurogenic Oropharyngeal Dysphagia.

Meng Dai, Ivy Cheng, Ayodele Sasegbon, Wanqi Li, Shaheen Hamdy

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meng DaiDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Centre for Gastrointestinal Sciences, Faculty of Biology, Medicine and Health, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.ORCID 0009-0003-9733-8189
Ivy ChengDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Centre for Gastrointestinal Sciences, Faculty of Biology, Medicine and Health, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.
Ayodele SasegbonDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Centre for Gastrointestinal Sciences, Faculty of Biology, Medicine and Health, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.
Wanqi LiDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Centre for Gastrointestinal Sciences, Faculty of Biology, Medicine and Health, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.
Shaheen HamdyDivision of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Centre for Gastrointestinal Sciences, Faculty of Biology, Medicine and Health, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.

Funding

National Natural Science Foundation of China 82402972
6 · The paper itself

Abstract

backgroundOropharyngeal sensory stimulation has been applied broadly in clinical dysphagia management, but evidence remains limited.

aimsWe aimed to determine its effectiveness in treating neurogenic dysphagia (ND). MATERIAL AND

methodsA systematic review and meta-analysis was conducted using studies from PubMed, EMBASE (via Ovid), CINAHL, Web of Science, and the Cochrane Library, searched up to January 2025. We included randomized controlled trials (RCT) comparing sensory stimulations, including electrical and gustatory stimulation, with sham controls or placebo. The outcome measurements included swallowing scales based on clinical and instrumental evaluations.

resultsWe included 16 RCTs (620 participants) in the meta-analysis. Overall, sensory stimulation significantly improved ND (n = 17, SMD [95% CI] = 0.80 [0.41, 1.20], p < 0.001; I

conclusionOropharyngeal sensory stimulation improves swallowing function and decannulation in ND, with minimal adverse effects. While electrical stimulation shows clear benefits, gustatory effects remain inconclusive. Further studies are warranted to optimize protocols and confirm efficacy.

Indexed as

Deglutition DisordersElectric Stimulation TherapyDeglutitionHumansRandomized Controlled Trials as TopicTreatment Outcomedysphagiameta‐analysisneurogenicsystematic reviewtreatment

Identifiers

PMID40625241
PMCPMC12235329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.