Postprandial glycemic response in different ethnic groups in East London and its association with vitamin D status: Study protocol for an acute randomized crossover trial.

Honglin Dong, Christian Reynolds, Saiful Islam, Swrajit Sarkar, Sophie Turner

Abstract readClinical Trial Protocol

In one paragraph

Article in Nutrition and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Habitual nutrient intakes and postprandial glycaemic responses to glucose and orange juice among ethnically diverse adults in London: an exploratory cross-sectional analysis.Frontiers in nutrition · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Honglin DongThe School of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0003-2225-7256

Christian ReynoldsThe School of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0002-1073-7394

Saiful IslamThe School of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0002-3855-9307

Swrajit SarkarThe School of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0002-7888-0509

Sophie TurnerThe School of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID 0000-0002-7024-6132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundIn the UK, Black African-Caribbeans (ACs) and South Asians (SAs) have 3-6 times greater risks of developing type-2 diabetes mellitus (T2DM) and significantly higher prevalence of vitamin D (vitD) deficiency than White Caucasians. East London is among the areas with the highest prevalence of T2DM and the highest proportion of ethnic minority groups. This ethnic health inequality is ascribed to socioeconomic standing, dietary habits, culture, and attitudes, while biological diversity has rarely been investigated.AimThe study aims to investigate the difference in the postprandial glycemic response (PGR), an independent risk factor of T2DM, between ethnic groups (White Caucasians, SAs, and ACs) in East London and its association with vitD status.MethodsThis acute randomized crossover trial will recruit healthy adults (n = 106) in East London between November 2023 and March 2025. Two test drinks are consumed by participants (a glucose drink containing 75 g glucose and pure orange juice) on different occasions. PGRs are monitored before and after drinking every 30 min for up to 2 h via finger prick. A fasting blood sample obtained via phlebotomy will be used for plasma 25(OH)D and relevant tests. A knowledge/perception questionnaire about vitD and a 4-day food diary (analyzing vitD dietary intake) will also be collected. Data will be analyzed using a multiple linear regression model adjusted by confounding factors (age, gender, body mass index, and body fat percentage).SummaryThe study results will be disseminated through journals and conferences, and target stakeholders.

Indexed as

Blood GlucoseEthnicityPostprandial PeriodVitamin DVitamin D DeficiencyAdultCross-Over StudiesDiabetes Mellitus, Type 2FemaleHumansLondonMaleMiddle AgedRandomized Controlled Trials as TopicRisk FactorsWhite PeopleBlood GlucoseVitamin D25(OH)Dbody fat percentagebody mass indexethnic minorityoral glucose tolerance testPostprandial glycemiatype 2 diabetes

Identifiers

PMID40625194

DOI10.1177/02601060251356528

PMCPMC12660509

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.