ArticleDatabase : the journal of biological databases and curation2025
PLoV: a comprehensive database of genetic variants leading to pregnancy loss.
Article in Database : the journal of biological databases and curation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing.Molecular genetics & genomic medicine · 2026Article
- Pilot Study of Preconception Carrier Screening in Russia: Initial Findings and Challenges.Genes · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Pregnancy loss is an important reproductive health problem that affects many couples. Genetic factors play an important role in both spontaneous miscarriage and recurrent pregnancy loss, and the effect of genomic variants is recognized as one of the major causes of pregnancy loss in euploid foetuses. In this work, we extend our previous analysis of the genetic landscape of pregnancy loss and develop a Pregnancy Loss genetic Variant (PLoV) database to aggregate information about mutations that have been implicated in pregnancy loss. The database contains information about 534 genetic variants that have been observed in 421 cases across 47 studies, including foetus-only, parent-only, and trio-based studies. For each case, the database includes a detailed description of the phenotype, including ultrasound data (if provided in the original article). The genetic variants are scattered across all chromosomes in the human genome and affect a total of 292 unique genes. We provide a public access to the PLoV database at https://plovdb.ott.ru/. Database URL: https://plovdb.ott.ru/.
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