ArticleJournal of Korean medical science2025
Prognostic Significance of Fatty Liver Index for the Development of Hypertension and Cardiovascular Events in Populations With Suboptimal Blood Pressure.
Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The fatty liver index exhibits a dual association with chronic obstructive pulmonary disease: a machine learning-based analysis of two independent cohorts.Frontiers in nutrition · 2026Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuboptimal blood pressure (BP) is a precursor to clinical hypertension and is associated with BP-related morbidity and mortality. Non-alcoholic fatty liver disease, a metabolic disorder with an increasing incidence rate, is associated with cardiovascular diseases (CVDs). We investigated the association of fatty liver index (FLI) with incident hypertension and CVD outcomes in a large cohort of adults with suboptimal BP.
methodsWe included 179,028 Koreans with suboptimal BP and no traditional risk factors from the National Health Insurance Service-National Sample Cohort, who underwent health examinations between 2009 and 2014. All subjects were divided into two groups based on their BP: 'normal BP' group (systolic BP [SBP] 120-129, diastolic BP [DBP] 80-84 mmHg), and 'high-normal BP' group (SBP 130-139, DBP 85-89 mmHg). The incidences of new-onset hypertension and major adverse cardiac and cerebrovascular events (MACCEs) were analyzed in the two groups across quartiles. Multivariate Cox proportional hazards regression analysis assessed the association between the FLI and primary outcome.
resultsDuring a median follow-up of 8.3 years, 34,667 participants (19.36%) developed new-onset hypertension, which was significantly greater in the 'high-normal BP' group than in the 'normal BP' group (25.95% vs. 14.25%,
conclusionOver 8-9 years, 19.3% of Korean adults with suboptimal BP developed hypertension, and 1.87% experienced MACCEs without traditional risk factors. A higher FLI was independently associated with the development of hypertension and MACCEs. The FLI may be an important predictor of new-onset hypertension and adverse cardiovascular outcomes.
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