Evidence map›Paper›PMID 40624932›Full record

ArticleFuture medicinal chemistry2025

Sulfur/selenium-functionalized benzotriazoles as multifunctional antivirals targeting Zika & Chikungunya.

Luana S Gomes, Claudio C Cirne-Santos, Caroline de S Barros, Rafael R Batista, Matheus R de P Ignacio, Aldo S de Oliveira, Célia M Ronconi, Izabel C N de Palmer Paixão, Vanessa Nascimento

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luana S GomesSupraSelen Laboratory, Department of Organic Chemistry, Universidade Federal Fluminense, Institute of Chemistry, Niterói, RJ, Brazil.
Claudio C Cirne-SantosPostgraduate Program in Sciences and Biotechnology (PPBI), Universidade Federal Fluminense, Biology Institute, Niterói, RJ, Brazil.
Caroline de S BarrosPostgraduate Program in Sciences and Biotechnology (PPBI), Universidade Federal Fluminense, Biology Institute, Niterói, RJ, Brazil.
Rafael R BatistaLaboratory of Molecular Virology and Marine Biotechnology, Department of Cellular and Molecular Biology, Federal Fluminense University, Biology Institute, Niterói, RJ, Brazil.
Matheus R de P IgnacioLaboratory of Immunovirology, Department of Immunobiology, Federal Fluminense University, Biology Institute, Niterói, RJ, Brazil.
Aldo S de OliveiraGulbenkian Institute for Molecular Medicine (GIMM), Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Célia M RonconiDepartment of Inorganic Chemistry, Federal Fluminense University, Niterói, RJ, Brazil.
Izabel C N de Palmer PaixãoPostgraduate Program in Sciences and Biotechnology (PPBI), Universidade Federal Fluminense, Biology Institute, Niterói, RJ, Brazil.
Vanessa NascimentoSupraSelen Laboratory, Department of Organic Chemistry, Universidade Federal Fluminense, Institute of Chemistry, Niterói, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsEmerging arboviruses such as Zika virus (ZIKV) and Chikungunya virus (CHIKV) remain significant public health threats. This study aimed to evaluate the antiviral potential of six organochalcogen compounds against ZIKV and CHIKV. MATERIALS &

methodsCompounds were assessed for cytotoxicity and antiviral activity in Vero cells. Antiviral effects were determined using plaque reduction assays, time-of-addition studies, viral adsorption, and virucidal assays. Molecular docking and density functional theory (DFT) calculations were performed to investigate interactions with viral targets and electronic properties.

resultsCompounds

conclusionsThese findings highlight organochalcogen compounds as promising dual-action antiviral candidates with broad-spectrum activity against ZIKV and CHIKV. Further preclinical investigations are warranted to explore their therapeutic potential.

Indexed as

Antiviral AgentsChikungunya virusSeleniumSulfurTriazolesZika VirusAnimalsChikungunya FeverChlorocebus aethiopsDensity Functional TheoryHumansMicrobial Sensitivity TestsMolecular Docking SimulationStructure-Activity RelationshipVero CellsVirus ReplicationAntiviral AgentsSeleniumSulfurTriazolesantiviralArbovirusesmechanism of actionmolecular dockingorganochalcogensviral replication

Identifiers

PMID40624932
PMCPMC12296112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.