ArticleBiomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia2025
Association of controlling nutritional status score and long-term mortality in acute pulmonary embolism.
Article in Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimsPulmonary embolism (PE) is a life-threatening condition with significant short- and long-term mortality risk. Although existing risk stratification models focus on short-term outcomes, the role of nutritional status in predicting long-term mortality remains underexplored. This retrospective study investigated the prognostic value of the Controlling Nutritional Status (CONUT) score, a composite index derived from serum albumin, total cholesterol, and lymphocyte counts.
methodsA total of 274 patients with confirmed PE were treated at a tertiary care center between January 2021 and March 2023. The primary endpoint was long-term all-cause mortality, as assessed using hospital records and follow-up interviews.
resultsMultivariate analysis identified the CONUT score as an independent predictor of mortality (odds ratio [OR], 1.298; 95% confidence interval [CI], 1.066-1.580; P=0.009). A cut-off score of 2.5 demonstrated high prognostic accuracy (AUC, 0.844; sensitivity, 89%; specificity, 72%). Patients with higher CONUT scores exhibited increased inflammatory marker levels, lower serum albumin levels, and worse outcomes.
conclusionThese findings highlight CONUT score as a simple and cost-effective tool for assessing nutritional and inflammatory status, enabling improved long-term risk stratification in patients with PE. Future studies should validate these results in diverse populations and evaluate the impact of targeted nutritional and anti-inflammatory interventions on patient outcomes.
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