Evidence map›Paper›PMID 40624890›Full record

ArticleAnnals of medicine2025

Maternal nitrate supplementation improves offspring cardiometabolic outcomes in obese pregnancies.

Kristi M Crowe-White, Katelyn E Senkus, Janie C DiNatale, Arlin B Blood, Taiming Liu, Meijuan Zhang, Khondoker Adeba Ferdous, Rebecca Bloch, Han-A Park

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristi M Crowe-WhiteDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0003-2497-4582
Katelyn E SenkusDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
Janie C DiNataleDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
Arlin B BloodLoma Linda University School of Medicine, Loma Linda, CA, USA.
Taiming LiuLoma Linda University School of Medicine, Loma Linda, CA, USA.
Meijuan ZhangLoma Linda University School of Medicine, Loma Linda, CA, USA.
Khondoker Adeba FerdousDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
Rebecca BlochDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.
Han-A ParkDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity during pregnancy is associated with excess adiposity and metabolic abnormalities in offspring due to fetal programming. Although the impact of dietary nitrate on cardiometabolic health has been established, it is unknown if maternal dietary nitrate intake would exhibit similar benefits to offspring. This study assessed cardiometabolic outcomes in offspring of Sprague-Dawley rats fed a high fat diet (HFD) with or without inorganic nitrate.

methodsEight-week-old female rats (

resultsPrior to mating, HFD and HFDN females exhibited significantly greater BW and fat mass (

conclusionsResults suggest periconceptional and prenatal nitrate supplementation may beneficially impact cardiometabolic outcomes of offspring born from an overweight or obese pregnancies including body weight, abdominal circumference, glucose dynamics, and lipid profiles. Further, results suggest that maternal intake of dietary nitrate impacts cellular responses during fetal development, thus regulating energy metabolism of offspring. .

Indexed as

NitratesObesityPrenatal Exposure Delayed EffectsAnimalsBody CompositionDietary SupplementsDiet, High-FatFemaleMalePregnancyRatsRats, Sprague-DawleyNitratescardiometabolic outcomesNitrate supplementationobesityoffspringoverweightpreclinical studypregnancy

Identifiers

PMID40624890
PMCPMC12239232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.