ArticleJournal of hepato-biliary-pancreatic sciences2025
Prevalence of Pancreaticobiliary Maljunction and High Confluence of the Pancreaticobiliary Ducts: True Incidence of Gallbladder Cancer.
Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pancreaticobiliary Maljunction Independently Predicts Early Recurrence after Surgical Resection for Gallbladder Carcinoma without Hepaticojejunostomy: A Propensity-Weighted Cohort Study.Annals of surgical oncology · 2026Article
- Application of endoscopic retrograde cholangiopancreatography in children with common bile duct microdilation: a single-center retrospective cohort study of 36 cases.BMC pediatrics · 2025Article
- Liquid biopsy in biliary tract cancers: early diagnosis, precision therapy, and prognostic evaluation.Frontiers in oncology · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough pancreaticobiliary maljunction (PBM) is associated with a high incidence of biliary cancer, it often goes undiagnosed. This means that the true prevalence of PBM and the incidence of biliary cancer are unknown. High confluence of the pancreaticobiliary ducts (HCPBD) may be an intermediate PBM variant, though reports are scarce. In this study, we aimed to determine the true prevalence of PBM and HCPBD and the actual incidence of biliary cancer.
methodsWe retrospectively analyzed data from adults who underwent cholecystectomy for benign gallbladder disease and compared them to those with gallbladder and bile duct cancers. The common channel (CC) and narrow distal segment (NDS) were measured using magnetic resonance cholangiopancreatography to diagnose PBM and HCPBD.
resultsPBM and HCPBD were identified in 0.44% and 0.88% of 2046 benign cholecystectomies, 16% and 4.2% of gallbladder cancers, and 1.3% and 3.8% of bile duct cancers, respectively (p < 0.01).
conclusionsThe overall prevalence was 0.44%. Combined with national data, the gallbladder cancer incidence in PBM was estimated to be 2.4% over one decade, which is 38-fold higher than that in the general population. Approximately 1% of the population have HCPBD, which may be a risk factor for biliary cancer.
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