Evidence map›Paper›PMID 40624721›Full record

ArticleNutrition & metabolism2025

Dietary factors and risk for endometriosis: a Mendelian randomization analysis.

Xia Zhang, Qiaomei Zheng, Lihong Chen

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Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Xia ZhangDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Qiaomei ZhengDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. qiaomeizheng@126.com.
Lihong ChenDepartment of Obstetrics and Gynecology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. fyfck3761@163.com.

Funding

Fujian Provincial Health Technology Project 2024CXA025Joint Funds for the Innovation of Science and Technology, Fujian Province 2023Y9051Startup Fund for scientific research, Fujian Medical University 2023QH1072
6 · The paper itself

Abstract

aimsObservational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR).

methodsWe performed a two-sample MR analysis to investigate the effects of 18 diet-related exposure factors (alcoholic drinks per week, alcohol intake frequency, processed meat intake, poultry intake, beef intake, non-oily fish intake, oily fish intake, pork intake, lamb/mutton intake, bread intake, cheese intake, cooked vegetable intake, tea intake, fresh fruit intake, cereal intake, salad/raw vegetable intake, coffee intake, dried fruit intake) on the risk of endometriosis using summary statistics from the genome-wide association study (GWAS). The inverse variance weighted (IVW) method was used to deduce the causal association between dietary factors and endometriosis, and sensitivity analyses were further performed.

resultsProcessed meat intake (OR = 0.550; 95%CI:0.314-0.965; p = 0.037) and salad / raw vegetable intake (OR = 0.346; 95%CI:0.127-0.943; p = 0.038) were discovered as protective factors for endometriosis. Heterogeneity test revealed no significant heterogeneity (processed meat intake: p

conclusionThese findings suggest that processed meat intake and salad/raw vegetable intake are associated with a decreased risk of endometriosis, but further investigation is required.

Indexed as

Causal associationDietary intakeEndometriosisMendelian randomizationProcessed meat intakeSalad/raw vegetable intake

Identifiers

PMID40624721
PMCPMC12236032

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