ArticleGenome biology2025
Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns.
Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Replication origin flexibility: a tool to mitigate the hazards of excess replication.Trends in genetics : TIG · 2026Review
- Adaptive Replication Fork Acceleration by CDK1-Cyclin B1 Sustains Genome Duplication despite Impaired Origin Firing.bioRxiv : the preprint server for biology · 2026Article
- Dynamic regulation of origin firing factors links CDK activity to dormant origin activation.Nature communications · 2026Article
- Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication.Nature communications · 2025Article
- Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns.Genome biology · 2025Article
- Due-B Is dispensable for early development and genome duplication in vertebrates.bioRxiv : the preprint server for biology · 2025Article
- Dynamic regulation of origin firing factors links CDK activity to dormant origin activation.bioRxiv : the preprint server for biology · 2025Article
- Selective interactions at pre-replication complexes categorize baseline and dormant origins.Nature communications · 2025Article
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Abstract
backgroundThe selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well defined. Potential DNA replication origins are licensed through the recruitment of a pair of minichromosome maintenance complexes (MCMs). In yeast, a subset of MCMs is selected for initiation by the SLD3-SLD7 firing factors during G1. Like in yeast, excessive numbers of MCM complexes are loaded onto chromatin during G1 in human cells, but it is unclear how MCMs are selected for firing.
resultsWe examine genomic binding locations for TICRR/TRESLIN and MTBP, the human orthologs for the yeast replication initiation factors Sld3 and Sld7. TRESLIN and MTBP binding patterns are detectable in a G1 synchronized population and have a higher binding signal compared to asynchronously cycling cells. MTBP binds to early-mid replicating regions in an early S population. Our data suggest MTBP is dependent on TRESLIN for proper association with chromatin during G1 but not S phase. We show that TRESLIN and MTBP binding during G1 does not require origins licensed with loaded MCMs.
conclusionsWe provide evidence for a chromatin binding mechanism of TRESLIN-MTBP during G1 that is dependent on TRESLIN and does not require interactions with licensed origins. MTBP binding location and footprint during S phase differs from that seen in G1, implicating two separate modes of binding. These data highlight binding mechanisms for DNA replication initiation factors in human cells that have diverged from those shown in yeast, suggesting differences in origin selection.
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