Evidence map›Paper›PMID 40624626›Full record

ArticleBMC genomics2025

Mechanism of Myh3 gene regulation of intramuscular fat content in Beijing black pigs via the MAPK signaling pathway.

Yunyan Luo, Gaoxiao Xu, Chunguang Zhang, Zuochen Wen, Han Chu, Yuxing Dai, Liang Hong, Jianbin Zhang, Akpaca Samson Vignon, Chao Sun and 2 more

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yunyan Luo *Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Gaoxiao Xu *Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China.
Chunguang Zhang *Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Zuochen WenTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Han ChuTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Yuxing DaiTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Liang HongTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Jianbin ZhangTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Akpaca Samson VignonTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.
Chao SunTianjin Key Laboratory of Green Ecological Feed, Tianjin modern Tianjiao Agricultural Technology Co, LTD, Tianjin, China.
Longchao ZhangInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China. zhanglongchao@caas.cn.
Lei PuTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China. puleiwork@tjau.edu.cn.

Funding

Anhui Natural Science Foundation Project 2208085MC76National Swine Industry Technology System CARS-35Tianjin Excellent Agricultural Science and Technology Special Commissioner and Support Projects 23ZYCGSN00230Tianjin Natural Science Foundation 20JCQNJC00650Tianjin Pig Industry Technology System Innovation Team ITTPRS2024006
6 · The paper itself

Abstract

backgroundIntramuscular fat (IMF) content is closely linked to meat tenderness and flavor. The Beijing Black pig, a renowned breed in China, serves as a valuable model for studying IMF traits, with implications for producing high-grade pork.

resultsThis study identified six single-nucleotide polymorphisms (SNPs) in the myosin heavy chain 3 gene (Myh3) that were significantly associated with IMF traits in Beijing Black pigs. To elucidate the molecular mechanism by which Myh3 affects porcine IMF development, cellular-level studies were conducted. Myh3 interference inhibited the proliferation and differentiation of porcine intramuscular preadipocytes while promoting p38 protein phosphorylation, whereas Myh3 overexpression had the opposite effects. Further investigation using p38 mitogen-activated protein kinase (MAPK) pathway inhibitors and activators revealed that inhibiting the pathway alleviated the suppressive effects of Myh3 interference on differentiation, while activating the pathway reduced the promotive effects of Myh3 overexpression.

conclusionOur findings demonstrate that Myh3 promotes intramuscular preadipocyte development by inhibiting the p38 MAPK signaling pathway, providing novel insights into the regulatory mechanisms of IMF development.

Indexed as

Adipose TissueMAP Kinase Signaling SystemMyosin Heavy ChainsAdipocytesAnimalsCell DifferentiationCell Proliferationp38 Mitogen-Activated Protein KinasesPolymorphism, Single NucleotideSwineMyosin Heavy Chainsp38 Mitogen-Activated Protein KinasesBeijing black pigIntramuscular fatMAPK signaling pathwayMyh3

Identifiers

PMID40624626
PMCPMC12236007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.