Evidence map›Paper›PMID 40624612›Full record

ArticleBMC gastroenterology2025

Intestinal microbiota in adults with cholangiocarcinoma identifies the dysregulated Blautia species and bile acid metabolic pathways.

Tianyu De, Tian Ma, Wei Wang, Xusheng An, Di Liu, Hongkun Yin, Qi Wang, Ting Zhao, Hao Wang

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Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Tianyu DeGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Tian MaGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Wei WangGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Xusheng AnPeking University First Hospital Ningxia Women and Children's Hospital, No. 127 Hupan Street, Jinfeng District, Yinchuan, Ningxia Hui, China.
Di LiuGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Hongkun YinSchool of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Qi WangGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Ting ZhaoPeking University First Hospital Ningxia Women and Children's Hospital, No. 127 Hupan Street, Jinfeng District, Yinchuan, Ningxia Hui, China.
Hao WangDepartment of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, 750004, China. wanghaograduate@126.com.

Funding

Ningxia Medical University Institutional Scientific Research Fund XZ2024033Program of Ningxia Science and Technology Leading Talent, China 2023GKLRLX17the Ningxia Gut Homeostasis and Chronic Disease Prevention and Treatment Scientific and Technological Innovation Team, China 2022BSB03112
6 · The paper itself

Abstract

backgroundCholangiocarcinoma (CCA) represents a significant global health concern. The gut and bile microbiota, which can influence the gut-liver axis and disease progression, have not been thoroughly characterized in CCA patients.

methodsWe selected two clinical centers at our hospital and collected stool samples from CCA patients and healthy controls (HC). These samples underwent whole-genome metagenomic shotgun sequencing, followed by analysis using both marker gene-based and assembly-based methods. Additionally, KEGG pathway enrichment was performed using the cholangiocarcinoma (CHOL) RNA-seq samples.

resultsOur results revealed distinct dysbiosis of the gut microbiota in our regional CCA patients. The results revealed greater heterogeneity in the gut microbiome of CCA patients compared to HC samples. We found Blautia species to be significantly less abundant in CCA samples, and can distinguish CCA patients from HC. Blautia can also play a role in influencing the modification of secondary bile acids. Additionally, down-regulation of arachidonic acid and linoleic acid metabolism was observed in the tumor tissues of CHOL patients. In summary, the results revealed significant heterogeneity difference in the gut microbiome of CCA patients compared to HC samples, and detected the specifically decreased Blautia species in CCA patients, suggesting that Blautia may influence bile acid metabolic pathways. Further investigation is warranted to explore Blautia as a potential biomarker for CCA.

Indexed as

Bile Acids and SaltsBile Duct NeoplasmsCholangiocarcinomaDysbiosisEubacterialesGastrointestinal MicrobiomeAdultAgedCase-Control StudiesFecesFemaleHumansMaleMetabolic Networks and PathwaysMiddle AgedBile Acids and SaltsBacterial floraBlautiaCholangiocarcinomaMicrobiomarkers

Identifiers

PMID40624612
PMCPMC12235764

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