Trial reportBMC anesthesiology2025
Ultrasound-guided mandibular nerve block combined with superficial cervical plexus nerve block in patients undergoing radical surgery for tongue canceron: a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
backgroundThis prospective randomized controlled trial evaluates the effectiveness of bilateral mandibular nerve block and bilateral superficial cervical plexus nerve block under general anesthesia for patients undergoing extensive tongue cancer surgery. Given the considerable size of the surgical area and the prolonged duration associated with radical tongue cancer procedures, these factors significantly hinder postoperative recovery, particularly in elderly patients.
methodsFor this study, 60 patients scheduled for elective radical tongue cancer surgery were enlisted. These individuals were methodically allocated into three distinct groups through randomization: a group receiving both mandibular and superficial cervical plexus nerve blocks (MC group, n = 20), a group receiving only the mandibular nerve block (M group, n = 20), and a group subjected solely to the superficial cervical plexus nerve block (C group, n = 20).
resultsDuring the first 12 h postoperatively, VAS scores in groups M and C were significantly higher than those in group MC (P < 0.001). The proportion of patients requiring activation of the patient-controlled analgesia pump was greater in groups M and C (45% and 55%, respectively) than in group MC (10%; P = 0.021). Postoperative MAP and HR increased above baseline in groups M and C, and both parameters were significantly elevated compared with group MC (P = 0.03). At the time of tongue incision, group C differed significantly from group M (mean difference, 95% CI 2.43-8.17; P < 0.001) and group MC (mean difference, 95% CI 4.33-10.07; P < 0.001). QOR-15 scores at 24 h and 48 h postoperatively were higher in group MC (91.10 ± 4.98 and 92.65 ± 4.88, respectively) than in group M (83.50 ± 5.89 and 87.95 ± 5.59; P < 0.001) and group C (83.15 ± 6.24 and 88.90 ± 5.63; P < 0.001). Intraoperative remifentanil and sufentanil consumption was lower in group MC than in groups M and C (P < 0.001).
conclusionsUtilizing ultrasound guidance for mandibular and superficial cervical plexus nerve blocks under general anesthesia substantially mitigates postoperative pain and enhances recovery rates following extensive tongue cancer surgeries, with no significant adverse effects observed.
trial registrationChina Clinical Trial Registration Center (registration number ChiCTR2400086380).
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