Evidence map›Paper›PMID 40624594›Full record

ArticleInfectious diseases of poverty2025

Trypanosoma dionisii in China: ecology and tentative epidemiology.

Qin Liu, Mu-Xin Chen, Yu-Chun Cai, Yuan-Yuan Li, Zi-Yi Wang, Yun-Hai Guo, Yu-Wan Hao, Jing-Bo Xue, Yi-Dan Jing, Fan-Na Wei and 18 more

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Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

28 authors.

Qin LiuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Mu-Xin ChenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yu-Chun CaiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yuan-Yuan LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Zi-Yi WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yun-Hai GuoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yu-Wan HaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Jing-Bo XueNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yi-Dan JingNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Fan-Na WeiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Yong-Bin WangShandong Institute of Parasitic Disease, Shandong First Medical University (Shandong Academy of Medical Sciences), Jining, 272033, Shandong, China.
Yue-Jin LiShandong Institute of Parasitic Disease, Shandong First Medical University (Shandong Academy of Medical Sciences), Jining, 272033, Shandong, China.
Hai-Fang WangShandong Institute of Parasitic Disease, Shandong First Medical University (Shandong Academy of Medical Sciences), Jining, 272033, Shandong, China.
Jun-Ling SunNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, 102299, China.
Ya-Li WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, 102299, China.
Gang WangDepartment of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Na WangDisease Control and Prevention Center of Dongying City, Dongying, 257092, Shandong, China.
Nai-Li GuoDisease Control and Prevention Center of Dongying City, Dongying, 257092, Shandong, China.
Jian-Cun FangDisease Control and Prevention Center of Dongying City, Dongying, 257092, Shandong, China.
Wei-Xiao ChenKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Xun-Ming ZhouKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Yang YuSchool of Life Sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Yi ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Jun-Hu ChenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Qiang WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China.
Shi-Zhu LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 20025, China. lisz@chinacdc.cn.
Ge YanShandong Institute of Parasitic Disease, Shandong First Medical University (Shandong Academy of Medical Sciences), Jining, 272033, Shandong, China. gey919@aliyun.com.
Qun LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, 102299, China. liqun@chinacdc.cn.

Funding

Clinical Research Special Project of Shanghai Municipal Health Commission 202140215National Natural Science Foundation of China No. 32161143036National Natural Science Foundation of China No. 32311540013Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai GWVI-11.1-12
6 · The paper itself

Abstract

backgroundTrypanosoma dionisii, one of several species that parasitizes Chiroptera worldwide, was first reported in a 30 year-old pregnant woman in China. It is important to improve our understanding of ecological and epidemiological patterns to identify potential transmission vectors and to estimate the risk of T. dionisii infection in the local population as well as in various species of domestic and wild animals.

methodsWe performed an ecological survey with epidemiological features in the area where the first T. dionisii case was found, including parasitological and serological tests and local demographic information for six surrounding villages. Sylvatic and domestic mammals and potential vector organisms in the same locality were investigated by nested-PCR for Trypanosoma and the phylogenetic analysis was performed.

resultsA total of 241 samples from the local population were screened for trypanosomiasis by parasitological and serological tests with no positive cases identified. However, 11 out of 18 bats collected from the village tested positively for Trypanosoma spp. by microscopy and nested-PCR, while 9 were positive for T. dionisii and 2 for T. vespertilionis. With regard to cats, 5 from a pet hospital in local showed 3 were co-infected with of T. dionisii and T. vespertilionis, and one having T. dionisii only, as well as one of the 29 animals examined was found infected with T. vespertilionis. Other animals seemed even less affected as all 163 blood samples collected from livestock and poultry, such as cows, sheep, chickens, ducks and geese, tested negative. Also 35 mosquito and mite pools tested negatively, while 4 out of 30 tick pools tested positive by nested-PCR with their sequences close to T. conorhini.

conclusionsThe survey indicates that a natural epidemic foci of T. dionisii, exists in Dongying Region, Shandong Province, China. Although no evidence of a high risk for human epidemic was found, the widespread presence of this parasites in bat species and a relatively high infection rate observed in the surveyed cats and dogs emphasize the emerging threat it poses to human health. Further surveillance and analysis are warranted to evaluate the transmission risk.

Indexed as

ChiropteraTrypanosomaTrypanosomiasisAnimalsCatsChinaDogsFemaleHumansMalePhylogenyBatsChinaCo-infectionCompanion animalsHuman trypanosomiasisTrypanosoma dionisiiTrypanosoma vespertilionis

Identifiers

PMID40624594
PMCPMC12232846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.