Evidence map›Paper›PMID 40624571›Full record

ArticleBMC psychology2025

Detecting the contribution of V5/MT in reading, reading-related tasks, eye-movements and EEG-oscillations in children and adolescents with developmental dyslexia via high-definition tDCS: a protocol study.

Federica Somma, Giulia Lazzaro, Samy Rima, Kristina Rainich, Christa Müller-Axt, Michael Christoph Schmid, Stefano Vicari, Katharina von Kriegstein, Deny Menghini

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05972200 (Probing the Efficacy of V5/MT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05972200 narecruitingnot on this map

Probing the Efficacy of V5/MT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2023 to 2026Enrolled36ConditionsDevelopmental DyslexiaArmsActive HD-tDCS over V5/MT, Active HD-tDCS over V1, Sham HD-tDCS over V5/MT or V1
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Federica Somma *Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Giulia Lazzaro *Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Samy RimaDepartment of Neuro- and Movement Sciences, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Kristina RainichChair of Cognitive and Clinical Neuroscience, Faculty of Psychology, Dresden University of Technology, Dresden, Germany.
Christa Müller-AxtChair of Cognitive and Clinical Neuroscience, Faculty of Psychology, Dresden University of Technology, Dresden, Germany.
Michael Christoph SchmidDepartment of Neuro- and Movement Sciences, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Stefano VicariChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Katharina von KriegsteinChair of Cognitive and Clinical Neuroscience, Faculty of Psychology, Dresden University of Technology, Dresden, Germany.
Deny MenghiniChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. deny.menghini@opbg.net.

Funding

ERA-Net NEURON ReDyslexia
6 · The paper itself

Abstract

backgroundNeuroscientific theories of Developmental Dyslexia (DD) primarily focus on language-related dysfunctions and their associated brain networks. However, DD is also associated with alterations in sensory pathways. For example, there is reduced connectivity in DD, in comparison to controls, between the left lateral geniculate nucleus (LGN) and V5/MT, a motion-sensitive visual area implicated in reading. Most neurostimulation studies in children with DD target language-related brain regions to improve reading, often overlooking motion-sensitive visual areas. Our study aims to target left V5/MT activity using high-definition transcranial Direct Current Stimulation (hd-tDCS) to modulate reading, related processes and physiological mechanisms in children with DD.

methodsUsing a triple-blind, within-subjects design, 36 children and adolescents (aged 8-13 years) will undergo three conditions: (i) active hd-tDCS over left V5/MT; (ii) active hd-tDCS over V1 (control-site condition); (iii) sham hd-tDCS over left V5/MT or V1 (sham condition). Participants will read a text during each hd-tDCS condition. We will collect data on reading (text, lists of words and nonwords), reading-related processes (visual motion perception, rapid automatized naming of letters and numbers, phoneme blending), and physiological measures (eye movements, EEG-oscillations). DISCUSSION: The results of the study could elucidate the role of V5/MT in reading and reading-related processes and demonstrate the neurophysiological effects of V5/MT stimulation. This study may enhance our understanding of how hd-tDCS can induce reading improvement and guide neurobiological-based interventions for children and adolescents with DD.

trial registrationThe study was registered at ClinicalTrials.gov (ID: NCT05972200) on 8 April 2023.

Indexed as

DyslexiaEye MovementsReadingTranscranial Direct Current StimulationVisual CortexAdolescentChildElectroencephalographyFemaleHumansMaleRandomized Controlled Trials as TopicBrain stimulationLeft lateral nucleus geniculatePredictive coding theoryReading disordersSensory pathwaysVisual domain

Identifiers

PMID40624571
PMCPMC12235968

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.