ArticleOrphanet journal of rare diseases2025
Physical fitness and level of physical activity in adult patients with Marfan syndrome.
Article in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Skeletal muscle alterations in Marfan syndrome: a systematic review.Journal of muscle research and cell motility · 2025Pooled it
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMarfan syndrome (MFS) is a rare connective tissue disorder adversely affecting several organ systems. This study evaluated the physical fitness and level of physical activity of Swedish adults with MFS with particular reference to age and sex.
methodsIncluded were patients with MFS aged ≥ 18 years, registered in the physiotherapy registry at the Adult Congenital Heart Disease unit of Sahlgrenska University Hospital/Östra who had completed at least one physical fitness test.
resultsOf the 1,894 registered patients, 41 met the inclusion criteria, and 17 (42%) were women. Women with MFS had lower exercise capacity (85.8 [32.3] vs. 123.0 [33.4] W, p = 0.003) and muscle function (handgrip strength 57.6 [18.8] vs. 117.4 [37.3] lbs, p < 0.001; shoulder abduction: 4.4 ± 1.5 vs. 7.4 ± 1.9 kg, p < 0.001) than men with MFS. Adults with MFS had significantly lower exercise capacity than reference values (p < 0.001). Both men and women with MFS had decreased muscle function (left and right heel lifts: p < 0.001 for both; handgrip strength: p = 0.021 for women; shoulder abduction: p < 0.001 for men; timed-stands test: p = 0.007 for women, p = 0.009 for men; compared with reference values. Overall, 71% of the patients reached the current physical activity recommendations of 500-1,000 metabolic equivalent of task (MET) minutes per week.
conclusionsThe majority of adults with MFS were sufficiently physically active; however, physical fitness was reduced. Further research is needed to determine whether individualized exercise regimes can improve physical fitness in adults with MFS.
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