Evidence map›Paper›PMID 40624484›Full record

Trial reportBMC anesthesiology2025

Comparison of intravenous nalbuphine and sufentanil on the median effective effect-site concentration of propofol to attenuate the response to cervical dilation during hysteroscopy: a double-blind, dose-response study.

Shu-Xi Li, Yan-Hong Zhou, Ying-Jie Yang, Qian Wang, Wan Lei, Jian-Jun Shen, Xin-Zhong Chen, Li-Li Xu

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shu-Xi Li *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Yan-Hong Zhou *Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Ying-Jie YangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Qian WangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Wan LeiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Jian-Jun ShenDepartment of Anesthesia, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Xin-Zhong ChenDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China.
Li-Li XuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, China. xulili@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNalbuphine, a synthetic opioid receptor agonist, exhibits comparable analgesic activity to morphine while demonstrating superior safety. Recent reports suggest that it is more effective than sufentanil in relieving uterine contraction pain. The objective of our study was to investigate the role of nalbuphine in reducing effect-site propofol concentration (Ce

methodsNinety patients having monitored anesthesia care for hysteroscopy were randomized to receive 0.15 mg·kg

resultsThe calculated EC

conclusionsDuring hysteroscopic surgery, when compared with sufentanil, 0.2 mg·kg

trial registrationThe study was then registered on August 9th, 2023 at the Chinese Clinical Trial Registry which participates in the World Health Organization International Clinical Trials Registry Platform (Identifier: ChiCTR2300074513) before enrolling the first participant and written informed consent was obtained by each patient.

Indexed as

Analgesics, OpioidAnesthetics, IntravenousHysteroscopyNalbuphinePropofolSufentanilAdultDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMiddle AgedAnalgesics, OpioidAnesthetics, IntravenousNalbuphinePropofolSufentanilCervical dilationHysteroscopyNalbuphinePropofol

Identifiers

PMID40624484
PMCPMC12232795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.