Evidence map›Paper›PMID 40624464›Full record

ArticleBMC psychiatry2025

Chain mediation of anxiety and suicidal ideation: a 2021-2025 cross-sectional analysis in Chinese temporomandibular disorders patients.

Ruopeng Zhao, Zheng Ye, Hongyu Ming, Jingran Peng, Po-Kam Wo, Haolun Yang, Liming Zhang, Xin Xiong

Abstract read
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruopeng Zhao *Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zheng Ye *Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Hongyu MingState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Jingran PengCollege of Medical Technology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Po-Kam WoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China.
Haolun YangRehabilitation Medicine Center, Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Liming ZhangRehabilitation Medicine Center, Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. 451597870@qq.com.
Xin XiongState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14 Section 3, Renmin South Road, Chengdu, 610041, Sichuan, China. drxiongxin@scu.edu.cn.

Funding

Clinical Research Project of West China Hospital of Stomatology, Sichuan University LCYJ-2023-YY-2National Natural Science Foundation of China 82301129
6 · The paper itself

Abstract

backgroundChronic musculoskeletal disorders are risk factors for suicidal ideation (SI). As a musculoskeletal condition, temporomandibular disorders (TMDs) are frequently associated with pain, psychological distress, and reduced quality of life, all of which may contribute to SI. However, the study of SI in TMDs is relatively scarce, and its influencing factors and pathways of impact have not been fully explored. This study aimed to investigate the factors affecting SI and the pathways of its influence.

methodsThis cross-sectional study included 934 TMDs patients and collected demographic information, anxiety levels, pain severity, and TMD-related quality of life (TMD-QoL) using questionnaires. Correlation and mediation analyses were conducted to explore their relationships.

resultsAnxiety was associated with SI (OR = 6.74, 95% CI [3.46-13.13], p < 0.001), even after adjustment (OR = 6.70, 95%CI [3.42-13.09], p < 0.001). And multiple domains of the TMD-QoL, such as psychological discomfort (OR = 3.61, 95%CI [2.19-5.96], p < 0.001), social disability (OR = 4.66, 95%CI [2.67-8.13], p < 0.001), were linked to SI. The association between anxiety on SI was mediated by pain (0.11, 95%CI [0.07-0.15], p < 0.001) and impact on TMD-QoL (0.25, 95%CI [0.18-0.32], p < 0.001).

conclusionsThis study underscores the need to incorporate psychological screening into the clinical management of TMDs to identify risk factors for SI. However, this study is limited by its cross-sectional design, which precludes the exploration of causal relationships. Future longitudinal studies are necessary to further validate these pathways.

Indexed as

AnxietySuicidal IdeationTemporomandibular Joint DisordersAdultChinaCross-Sectional StudiesFemaleHumansMaleMediation AnalysisMiddle AgedQuality of LifeRisk FactorsYoung AdultAnxietyOrofacial painQuality of lifeSuicidal ideationSuicide preventionTemporomandibular disorders

Identifiers

PMID40624464
PMCPMC12236030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.