Evidence map›Paper›PMID 40624412›Full record

ArticleSurgical endoscopy2025

Does helicobacter pylori infection impact reflux symptoms after sleeve gastrectomy? A pilot study using patient reported outcome measures (PROMs).

Isabella Amaniera, Nicole L Petcka, Varnette Robinson, Sheethal Reddy, Jamil Stetler, Ankit D Patel, Omobolanle Oyefule, Jahnavi Srinivasan, Dominic Papandria, S Scott Davis and 3 more

Abstract read
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Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isabella AmanieraDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Nicole L PetckaDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Varnette RobinsonEHI Office of Quality, Emory University Hospital Midtown, Atlanta, GA, USA.
Sheethal ReddyDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Jamil StetlerDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Ankit D PatelDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Omobolanle OyefuleDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Jahnavi SrinivasanDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Dominic PapandriaDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
S Scott DavisDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Edward LinDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Danny MouDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA.
Elizabeth M HechenbleiknerDepartment of Surgery, Emory University School of Medicine, 550 Peachtree Street Northeast, Medical Office Tower, 7th Floor, Atlanta, GA, 30308, USA. ehechen@emory.edu.ORCID http://orcid.org/0000-0002-0706-7860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between Helicobacter pylori (HP) infection and gastrointestinal symptoms after metabolic and bariatric surgery (MBS) is poorly understood. While sleeve gastrectomy (SG) can exacerbate reflux, there is limited literature evaluating the impact of HP infection on post-SG symptoms. We hypothesize that HP-positive SG patients will experience worse post-operative reflux and eating-related (ER) symptoms.

methodsA retrospective cross-sectional study comparing post-operative PROMs (patient-reported outcome measures) surveys was performed for HP-positive vs. HP-negative SG patients (2/2023 - 12/2024). Pre-operative HP status was determined via esophagogastroduodenoscopy and gastric biopsy testing. PROMs surveys administered were the gastroesophageal reflux disease health-related quality of life (GERD-HRQL) questionnaire and BODY-Q eating modules, assessing ER symptoms, behavior, and distress. Average post-operative survey scores were compared using independent sample t-tests; p-value < 0.05 was deemed statistically significant.

resultsOverall, 481 post-operative surveys were completed across 237 patients (80 surveys in the HP-positive cohort, 401 surveys in the HP-negative cohort); 17.7% of patients were HP-positive and 95.2% completed medical treatment. Comparison of post-operative BODY-Q scores revealed that the HP-positive group had a significantly lower ER symptoms score (73.79 ± 12.55 vs. 78.28 ± 12.32; p = 0.003) indicating worse symptoms. Compared to the HP-negative cohort, the HP-positive cohort experienced more frequent bloating (61.3% vs. 47.4%; p = 0.023) and regurgitation (32.5% vs. 18%; p = 0.003). Post-operative GERD-HRQL scores were significantly higher in the HP-positive group (5.76 ± 6.86 vs. 3.68 ± 5.64; p = 0.006) indicating worse reflux. The HP-positive group reported more heartburn after meals (45% vs. 25.9%; p < 0.001).

conclusionHP-positive patients reported worse post-operative survey results for ER symptoms including more frequent bloating and regurgitation. GERD-HRQL scores in the HP-positive cohort were significantly higher indicating worse reflux-associated symptoms and heartburn after meals. Future studies should explore the impact of HP infection on MBS patients with larger, diverse patient populations and other index procedures.

Indexed as

GastrectomyGastroesophageal RefluxHelicobacter InfectionsHelicobacter pyloriObesity, MorbidPostoperative ComplicationsAdultBariatric SurgeryCross-Sectional StudiesFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPilot ProjectsQuality of LifeHelicobacter pyloriPatient reported outcomes measureSleeve gastrectomy

Identifiers

PMID40624412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.