Evidence map›Paper›PMID 40624360›Full record

ArticleWorld journal of urology2025

Holmium laser enucleation of the prostate and strictures: long-term outcomes, stricture characteristics, and risk factors.

Maximilian Glienke, A Sigle, R Himmelsbach, M F von Bargen, M Schoenthaler, A Özkan, D S Schoeb, K Wilhelm, C Gratzke, A Miernik

Abstract read
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Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maximilian GlienkeDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany. Maximilian.glienke@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-6051-4404
A SigleDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
R HimmelsbachDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
M F von BargenDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
M SchoenthalerDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
A ÖzkanDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
D S SchoebDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
K WilhelmDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
C GratzkeDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.
A MiernikDepartment of Urology, Faculty of Medicine, Medical Centre, University of Freiburg, Hugstetter Straße 55, 79016, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHolmium laser enucleation of the prostate (HoLEP) is a well-established treatment for benign prostatic hyperplasia (BPH). However, long-term data on postoperative urethral strictures remain scarce. This study aimed to evaluate the incidence, anatomical characteristics, timing, and potential pre- and perioperative risk factors for stricture formation following HoLEP.

methodsA retrospective analysis was conducted on 1,724 patients who underwent HoLEP between September 2015 and October 2022. Patients with pre-existing urethral strictures were excluded. Data on demographics, surgical details, and postoperative outcomes were collected. Follow-up was achieved in 1,512 patients (87.7%) over a mean duration of 5.03 years. Urethral and bladder neck strictures requiring intervention were identified through clinical follow-up or structured telephone interviews. Risk factors were assessed using logistic regression.

resultsUrethral strictures (US) were found in 5.0% of patients and bladder neck strictures (BNS) in 2.0%. Most US were located in the bulbar urethra (90.7%) and developed within two years postoperatively. Smaller prostate volume and lower PSA were significantly associated with increased stricture risk. BNS risk was additionally linked to shorter operative time, lower laser energy, and less surgeon experience. Strictures were predominantly short-segmented; 21.1% were longer than 2 cm.

conclusionStricture formation after HoLEP, though infrequent, remains a relevant long-term complication. Identifying patients at higher risk based on prostate size, catheter use, and surgical parameters can help inform preventative strategies and improve postoperative counseling and outcomes.

Indexed as

Lasers, Solid-StateLaser TherapyPostoperative ComplicationsProstatectomyProstatic HyperplasiaUrethral StrictureUrinary Bladder Neck ObstructionAgedAged, 80 and overHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeBenign prostatic hyperplasie, BPHBenign prostatic obstruction, BPOBladder neck strictureHolmium laser enucleation, holepUrethral stricture

Identifiers

PMID40624360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.