Evidence map›Paper›PMID 40624303›Full record

ArticleScientific reports2025

Brown adipose tissue, anthropometric traits, and metabolic profiles in women with normal weight obesity.

Kumiko Dojo, Keiko Ishida, Sayuri Fuse-Hamaoka, Masafumi Aoki, Mai Tsunoda, Masaki Yamamoto, Noriyasu Ota, Takafumi Hamaoka

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kumiko Dojo *Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan.
Keiko Ishida *Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan.
Sayuri Fuse-HamaokaDepartment of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, 160-8402, Japan.
Masafumi AokiBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan.
Mai TsunodaBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan.
Masaki YamamotoBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan. yamamoto.masaki@kao.com.
Noriyasu OtaBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai- machi, Haga-gun, Tochigi, 321-3497, Japan.
Takafumi HamaokaDepartment of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, 160-8402, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence indicates that individuals with normal-weight obesity (NWO), characterized by a normal body mass index (BMI) but high body fat (BF) percentage, are at increased risk of cardiometabolic diseases. Brown adipose tissue (BAT) is crucial for cardiometabolic health. However, the connection between adipose tissue density and NWO remains elusive. A total of 90 women aged 30-59 with BMIs ranging from 18.5 to 32 were investigated. We measured BAT vascular density as the total hemoglobin concentration using near-infrared time-resolved spectroscopy (NIR-TRS). While the total, visceral, and subcutaneous fat areas were significantly higher in the NWO group than those in the normal-weight group, the BAT vascular density was significantly lower in the NWO group (49.83, 95% CI: 45.98, 53.67) than that in the normal-weight group (64.94, 95% CI: 57.71, 72.17) (p < 0.01). Multivariate regression analysis identified BAT vascular density as a significant predictor of BF percentage (β = -0.308, p < 0.001). These findings suggest that women with NWO have markedly lower BAT vascular densities than those exhibited by women in the normal-weight group, underscoring the remarkable association of BAT with BF accumulation and the development of obesity and cardiometabolic dysregulation.

Indexed as

Adipose Tissue, BrownMetabolomeObesityAdultAnthropometryBody Mass IndexFemaleHumansMiddle AgedBody fat percentageBrown adipose tissueCardiometabolic diseasesNear-infrared time-resolved spectroscopyNormal-weight obesityVascular density

Identifiers

PMID40624303
PMCPMC12234867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.