ArticleScientific reports2025
PIEZO1 activity promotes stemness in mesenchymal stem cells under shear stress and enhances protection of leukemia cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Piezo-type mechanosensitive ion channel component 1: a mechano-bioenergetic transducer in the tumour microenvironment.Annals of medicine · 2026Review
- Downregulation of PIEZO1 Activity Promotes Breast Cancer Cell Survival under Shear Stress by Modulating β-Catenin and BCL2.Cancer research communications · 2026Article
- Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory.Science advances · 2026Article
- Piezo1 Mechanosensor Expression in Rare Hematopoietic Cells Controls Systemic Inflammatory Response in Mice.Cells · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Mesenchymal stem cells (MSCs) differentiate into cells of multiple lineages and play an essential role in bone formation, tissue regeneration, immunomodulation and are also necessary to maintain hematopoiesis in bone marrow. The lineage commitment of MSCs into osteoblasts is controlled by several factors including mechanical signals from the microenvironment. Mechanosensor proteins regulate the interaction of the cells with the microenvironment and control several cellular functions. Here, we determined the cellular effects of PIEZO1, a mechanically activated ion channel protein on proliferation, differentiation, migration, and leukemia support of human bone marrow-derived MSCs (BM-MSCs). Activation of PIEZO1 negatively impacted the proliferation, osteogenic differentiation, and migration ability of BM-MSCs and PIEZO1 downregulation reduced the self-renewal and differentiation ability, but partially reversed the inhibitory effects of PIEZO1 activation (through yoda1) on differentiation and migration. PIEZO1 activity modulates the shear-stress response in BM-MSCs, resulting in downregulation of PIEZO1 expression. Concurrently, this reduction activates Notch signaling pathway and upregulates genes associated with stemness. In addition, PIEZO1 activity mediates the chemoprotective ability of BM-MSCs on leukemia cells by modulating the interaction between the MSCs and leukemia cells. Our findings suggest that a calibrated PIEZO1 activity is required in BM-MSCs to maintain their differentiation, proliferation and migration ability and PIEZO1 regulates the interaction of BM-MSCs with the hematopoietic cells.
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