Evidence map›Paper›PMID 40624272›Full record

ArticleInternal and emergency medicine2025

Sex-related differences among patients with reflex neurally mediated syncope.

Vincenzo Russo, Erika Parente, Angelo Comune, Thao Huynh, Moiz Tariq, Tiziana Assante, Valentina Parisi, Maddalena Conte, Gerardo Nigro, Michele Brignole

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Article in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vincenzo RussoCardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy. Vincenzo.russo@unicampania.it.
Erika ParenteCardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy.
Angelo ComuneCardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy.
Thao HuynhDivision of Cardiology, Department of Medicine, McGill Health University Center, Montreal, QC, Canada.
Moiz TariqDepartment of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Tiziana AssanteCardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy.
Valentina ParisiDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Maddalena ConteDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Gerardo NigroCardiology and Syncope Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli" - Monaldi Hospital, Naples, Italy.
Michele BrignoleIRCCS Istituto Auxologico Italiano, Faint & Fall Programme, Cardiology Unit and Department of Cardiovascular, Neural and Metabolic Sciences, S.Luca Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few studies have evaluated the effect of sex in patients with reflex neurally mediated syncope. The aim of our study was to describe the sex-related differences in clinical characteristics and responses to HUTT among a large population with syncope. 1845 consecutive patients who underwent HUTT for suspected or established reflex syncope were evaluated. The study population was dichotomized according to sex. The clinical characteristics, the HUTT positivity rate and responses were compared between the groups. The trends of blood pressure (BP) and heart rate (HR) and the HUTT positivity rate were analyzed across different age groups according to sex. 1845 patients (45 ± 20 years) were included; 938 were females. Females showed lower values of systolic BP with higher values of HR compared to males up to 49 years. The HUTT positivity rate was significantly lower in females compared to males (61.1% vs 66%; p = 0.03). After adjusting for age decades, females had a higher positivity rate than males until the age of 29 years. Females showed an overall significantly lower rate of cardioinhibitory response compared with males (22.2% vs 29.3%; p = 0.0005). Female patients with suspected reflex neurally mediated syncope showed a different hemodynamic profile characterized by lower BP values and higher HR values than males until the age of 49 years. The overall HUTT positivity rate was lower in females than in males; however, females had a higher positivity rate until the age of 29 years. The prevalence of cardioinhibitory response was lower in females.

Indexed as

Syncope, VasovagalAdultAgedAge FactorsBlood PressureFemaleHeart RateHumansMaleMiddle AgedSex FactorsSyncopeTilt-Table TestBradicardic phenotypeCardioinhibitory syncopeHead up tilt testHypotensive phenotypeSex differenceSyncope

Identifiers

PMID40624272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.