Evidence map›Paper›PMID 40624270›Full record

ArticleHistochemistry and cell biology2025

Uridine and uridine nucleotides as novel regulators of NUCB2/nesfatin-1 neuron activation: an immunohistochemical study.

N Hasanoğlu Akbulut, G Topal, C Koç, N Coşkan, B Salman, M Cansev, O Eyigor

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Article in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

N Hasanoğlu AkbulutFaculty of Medicine, Department of Histology and Embryology, Bursa Uludag University, Bursa, Türkiye.
G TopalFaculty of Medicine, Department of Histology and Embryology, Bursa Uludag University, Bursa, Türkiye.
C KoçFaculty of Medicine, Department of Pharmacology, Bursa Uludag University, Bursa, Türkiye.
N CoşkanFaculty of Medicine, Department of Histology and Embryology, Bursa Uludag University, Bursa, Türkiye.
B SalmanFaculty of Medicine, Department of Pharmacology, Bursa Uludag University, Bursa, Türkiye.
M CansevFaculty of Medicine, Department of Pharmacology, Bursa Uludag University, Bursa, Türkiye.
O EyigorFaculty of Medicine, Department of Histology and Embryology, Bursa Uludag University, Bursa, Türkiye. oeyigor@uludag.edu.tr.

Funding

Scientific Research Projects Foundation of the Bursa Uludag University TOA-2021-684
6 · The paper itself

Abstract

Nesfatin-1, identified as an anorexigenic neuropeptide in the hypothalamus, is activated by glutamatergic agonists and innervated by excitatory and inhibitory neurons. The uridine nucleotide uridine diphosphate was recently identified as a novel regulator of feeding-related neurons. However, the activating effects of uridine and uridine nucleotides on anorexigenic NUCB2/nesfatin-1 neurons are unknown. In this study, the activating effects of intracerebroventricularly administered uridine or uridine nucleotides (UMP, UDP, UTP) on NUCB2/nesfatin-1 neurons localized in the supraoptic (SON), paraventricular (PVN), and periventricular (PeV) nuclei were determined using c-Fos immunohistochemistry. Results were evaluated as the percentage of the ratio of c-Fos-expressing (activated) NUCB2/nesfatin-1 neurons to all NUCB2/nesfatin-1 neurons. It was determined that centrally administered uridine, UMP, and UTP activated a statistically significant number of NUCB2/nesfatin-1 neurons in the SON, PVN, and PeV, compared with the saline group (p < 0.05). At the same time, the slight increase in the neuronal activation seen following UDP application was not found to be significant. The results of this study show that NUCB2/nesfatin-1 neurons respond to uridine and uridine nucleotides in the form of neuronal activation, possibly through pyrimidinergic neurotransmission.

Indexed as

NeuronsUridineAnimalsImmunohistochemistryMaleNucleobindinsRatsRats, Sprague-DawleyRats, WistarNucb1 protein, ratNucb2 protein, ratNucleobindinsUridineHypothalamic nucleiNesfatin-1Neuronal activationNUCB2UridineUridine nucleotides

Identifiers

PMID40624270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.