ArticleScientific reports2025
Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Wireless Electroencephalography in Research on Children With Developmental Disabilities: Scoping Review.Journal of medical Internet research · 2026Article
- Cerebellar pathway diffusion MRI measures are linked to core autism symptoms in early adolescents aged 9 to 11 years.Brain structure & function · 2026Article
- Passive OPM-MEG paradigm reveals altered brain network organization in children with DLD.iScience · 2026Article
- Identification of Children With Autism Spectrum Disorder Based on Multidimensional EEG Feature Fusion Across Temporal-Spectral-Spatial Domains.Alpha psychiatry · 2026Article
- Hierarchical-Circular Model of Biological Memory: an integrative framework for pathogenesis and allostasis in neurodevelopmental disorders.Frontiers in behavioral neuroscience · 2026Article
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Authors and funding
4 authors.
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Abstract
Despite the breakthrough achievements in understanding structural and functional alterations of brain connectivity in autism spectrum disorder (ASD), the exact nature and type of such alterations are not yet clear due to conflicting reports of hyper-connectivity, hypo-connectivity, and-in some cases-combinations of both. In this work, we bring order to the debate using a network comparison technique to capture mesoscopic-scale differential patterns of functional connectedness. In particular, we leverage recent algorithmic advances in extracting contrast subgraphs to identify maximally different mesoscopic connectivity structures between two sets of networks from typically developed individuals and ASD subjects across different developmental stages. A significantly larger connectivity among occipital cortex regions and between the left precuneus and the superior parietal gyrus was found in ASD subjects. At the same time, reduced connectivity characterized the superior frontal gyrus and the temporal lobe regions. More importantly, our results reconcile within a single framework multiple previous separate observations about functional connectivity alterations in ASD.
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