Evidence map›Paper›PMID 40624007›Full record

ArticleNature communications2025

Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy.

Jiakun Guo, Jintao Huang, Zuliang Huang, Di Hu, Hujing Tan, Yan Wang, Chao Deng, Xiaoli Zhu, Zhiyuan Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiakun Guo *Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Jintao Huang *Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zuliang HuangBiomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Di HuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hujing TanBiomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Yan WangBiomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
Chao DengBiomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China. cdeng@suda.edu.cn.ORCID http://orcid.org/0000-0001-7697-9874
Xiaoli ZhuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China. zhuxiaoli90@163.com.
Zhiyuan ZhongBiomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Materials, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China. zyzhong@suda.edu.cn.ORCID http://orcid.org/0000-0003-4175-4741

Funding

National Natural Science Foundation of China (National Science Foundation of China) 51973149National Natural Science Foundation of China (National Science Foundation of China) 52373299
6 · The paper itself

Abstract

Transarterial chemoembolization (TACE) is a common clinical intervention used for unresectable liver tumors, but conventional embolic microspheres generally exhibit slack vascular stacking and suboptimal drug release. Here, we report tumor vessel-adaptable, adhesive, and absorbable microspheres (3Asphere) based on hyaluronic acid developed using microfluidic and radical polymerization techniques for sustained TACE therapy of liver tumors. 3Asphere presents uniform sizes, gradual degradation over two months, and fast encapsulation and sustained release of chemotherapeutics such as epirubicin, irinotecan, and cisplatin. Interestingly, 3Asphere with high elasticity enables robust vascular embolization, effectively blocking rabbit renal blood supply for over one month. In rabbit VX2 orthotopic liver tumors, 3Asphere actively binds to endothelial cells via CD44 and inhibits tumor growth, affording significant survival benefits compared to commercial Embosphere

Indexed as

Chemoembolization, TherapeuticLiver NeoplasmsMicrospheresAnimalsAntineoplastic AgentsCell Line, TumorCisplatinDrug LiberationEpirubicinHumansHyaluronan ReceptorsHyaluronic AcidIrinotecanMiceRabbitsAntineoplastic AgentsCisplatinEpirubicinHyaluronan ReceptorsHyaluronic AcidIrinotecan

Identifiers

PMID40624007
PMCPMC12234964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.