ArticleJournal of neurointerventional surgery2026
Medical and endovascular treatment for acute large vessel occlusion with mild stroke: a real-world nationwide registry.
Article in Journal of neurointerventional surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndovascular therapy (EVT) is standard treatment for large vessel occlusion in patients with a National Institutes of Health Stroke Scale (NIHSS) score ≥6, but its role in mild stroke (NIHSS score <6) remains uncertain.
objectiveTo explore the association between EVT and clinical outcomes in mild stroke.
methodsThis study prospectively enrolled consecutive patients with a mild stroke at 35 comprehensive stroke centers in China between January 2020 and December 2023. Patients were categorized into primary EVT (pEVT) or best medical management (BMM) groups. The primary outcome was an excellent outcome (modified Rankin Scale (mRS) score ≤1). Secondary outcomes included a good outcome (mRS score ≤2) and lowering of the mRS score. Safety endpoints were mortality and symptomatic intracranial hemorrhage. Outcomes were compared between groups using multivariable logistic regression and inverse probability of treatment weighting (IPTW).
resultsFinally, 307 patients were included: 117 received pEVT, and 190 received BMM. In the IPTW model, pEVT was associated with higher excellent (aOR=3.6, 95% CI 2.5 to 5.2) and good (aOR=4.0, 95% CI 2.5 to 6.6) outcomes, lower mortality (aOR=0.1, 95% CI 0.01 to 0.4), and a lower 90-day mRS (aOR=0.2, 95% CI 0.1 to 0.3), with similar sICH rates. Among the BMM group, 80 patients (42.1%) experienced early neurological deterioration (END), with 55 receiving rescue EVT (rEVT), and were still included in BMM group. In the multivariable model, the rEVT was related with higher excellent (aOR=7.2, 95% CI 1.4 to 37.9) and good (aOR=4.1, 95% CI 1.2 to 14.8) outcomes and a lower mRS (aOR=2.0, 95% CI 0.9 to 4.8).
conclusionsPrimary EVT significantly increases the likelihood of achieving an excellent outcome in mild stroke. Over 40% of patients with a mild stroke treated with BMM experienced END, and rEVT effectively improved the prognosis.
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