Evidence map›Paper›PMID 40623787›Full record

ArticleBMJ case reports2025

Overtraining Syndrome (OTS) in Three Endurance Athletes and Roads to Recovery.

Jeffrey B Kreher, Jan Stepanek, Robert Amrine, Satyajit Reddy

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffrey B KreherOrthopaedics, Mass General Brigham, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-3912-6992
Jan StepanekGeneral Internal Medicine & Mayo Clinic Aerospace Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Robert AmrineFamily Medicine Residency of Idaho, Boise, Idaho, USA.
Satyajit ReddyDepartment of Cardiovascular Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA Reddy.Satyajit@mayo.edu.ORCID http://orcid.org/0000-0002-2626-4165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overtraining syndrome (OTS) is a significant medical condition observed predominantly in endurance athletes and characterised by a decline in performance and disruptions in multiple physiological functions. Given the increasing popularity of endurance training and the complex nature of OTS diagnosis, there is a compelling need for comprehensive case studies. The case series summarises one professional runner, one competitive runner and one recreational runner who were diagnosed with OTS. Key parameters observed include symptoms, diagnostic journey, recovery initiatives and return-to-sport outcomes. All three athletes showed typical OTS manifestations, including impaired performance and multisystem dysfunction (ie, endocrine, nervous, immune and gastrointestinal systems). Following a mandated cessation from training, active recovery strategies were instituted. Two of the three athletes successfully returned to competition. Specific recovery patterns and potential relapse indicators were also identified. The comprehensive examination of the cases underscores the complex nature of OTS diagnosis, its multifaceted symptoms and the critical importance of structured recovery. The case series elucidates the importance of heightened awareness and early intervention to diagnose and manage OTS. In addition, we propose an anecdotal Return to Running Protocol individualised to the athlete's response.

Indexed as

AthletesCumulative Trauma DisordersEndurance TrainingReturn to SportRunningHumansOvertraining SyndromePhysical EnduranceCardiovascular medicineEndocrinologyFluid electrolyte and acid-base disturbancesNutrition and metabolismSports and exercise medicine

Identifiers

PMID40623787
PMCPMC12258013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.