Evidence map›Paper›PMID 40623731›Full record

ReviewBMJ open ophthalmology2025

Consideration of patient phenotypes in geographic atrophy due to age-related macular degeneration.

Rishi P Singh, Christina Y Weng, John W Kitchens, Jaclyn Quilantan, Roy Schwartz, Caroline R Baumal, Roger A Goldberg

Abstract readReview
In one paragraph

Review in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rishi P SinghDepartment of Ophthalmology, Cleveland Clinic, Cleveland, Ohio, USA singhr@ccf.org.ORCID 0000-0001-5859-8162
Christina Y WengDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-3135-1922
John W KitchensRetina Associates of Kentucky, Lexington, Kentucky, USA.
Jaclyn QuilantanApellis Pharmaceuticals Inc, Waltham, Massachusetts, USA.
Roy SchwartzApellis UK Limited, London, UK.
Caroline R BaumalApellis Pharmaceuticals Inc, Waltham, Massachusetts, USA.ORCID 0000-0002-3651-8210
Roger A GoldbergBay Area Retina Associates, Walnut Creek, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Geographic atrophy (GA) is a form of advanced age-related macular degeneration (AMD) affecting approximately 1 million people in the USA and 5 million globally. In this review, retinal imaging techniques used for diagnosis and monitoring progression of GA in AMD, and the risk factors associated with the development and progression of GA are summarised. To familiarise clinicians with common phenotypes of patients with GA, the clinical and imaging features that may lead to rapid progression of GA in various phenotypes are highlighted. With the recent US Food and Drug Administration approval of new GA treatments that reduce lesion growth, understanding the risk of progression to GA and factors contributing to GA growth may aid in patient selection and guide patient-level management and treatment.

Indexed as

Geographic AtrophyMacular DegenerationDisease ProgressionFluorescein AngiographyHumansPhenotypeRisk FactorsTomography, Optical CoherenceGeographic AtrophyImagingMacular Degeneration

Identifiers

PMID40623731
PMCPMC12243631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.