Evidence map›Paper›PMID 40623455›Full record

ArticleJournal of advanced research2026

A general strategy for the efficient utilization of Microbiocide by using polyacrylic acid sodium as a flexible framework material.

Weiyao Yan, Yuqi Huang, Gang Tang, Xiaohong Zhang, Yulu Liu, Gaohua Hu, Guangyao Yan, Jianhua Xiao, Zhiping Zhang, Yingbin Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weiyao YanState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Yuqi HuangState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Gang TangState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Xiaohong ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Yulu LiuState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Gaohua HuState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Guangyao YanState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Jianhua XiaoState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Zhiping ZhangKey Laboratory for Agro-Biodiversity and Pest Control of Ministry of Education, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China.
Yingbin LiKey Laboratory for Agro-Biodiversity and Pest Control of Ministry of Education, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China.
Yixiang LiuKey Laboratory for Agro-Biodiversity and Pest Control of Ministry of Education, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. Electronic address: lyxcm@126.com.
Yongsong CaoState Key Laboratory of Agricultural and Forestry Biosecurity, MARA Key Lab of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China. Electronic address: caoysong@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCopper sulfide nanoparticles are ideal carrier materials for the preparation of controlled release nano-systems that can effectively improve the utilization efficiency and environmental safety of microbicides because of their excellent antimicrobial activity, low environmental toxicity, and controllable structure.

objectivesThis study aims to elucidate the general rules of loading and release of drugs in pH-responsive nano-delivery systems based on CuS NPs and develop a general strategy for efficient utilization of microbicide and sustainable plant disease management.

methodsThree microbicide-loaded copper sulfide nanoparticles (Microbicide@PAS-CuS NPs) were fabricated via a one-pot route by using polyacrylic acid sodium (PAS) as a flexible framework carrier material and berberine sulfate (BBR), bronopol (BNP), and kasugamycin (KSM) as the loaded microbicides. The physicochemical properties, bioactivity, effective duration, genotoxicity, and plant safety of the obtained Microbicide@PAS-CuS NPs were characterized and evaluated systematically.

resultsThe results indicated that the encapsulation efficiency and microbicide loading capacity of Microbicide@PAS-CuS NPs increased with decreasing LogP values of the microbicides. The obtained Microbicide@PAS-CuS NPs were regular spherical nanoparticles with a uniform particle size, good dispersion stability, and high microbicide loading rate (ranging from 21.36 to 37.50 %) and could respond to the acidic microenvironments associated with pathogen infection to control release the microbicide. Because KSM and BNP were loaded into the channels of nanocapsules formed by incorporating Cu

conclusionThis study provides a universal strategy to increase the utilization efficiency and environmental safety of microbicides. Microbicide@PAS-CuS NPs have promising applications as novel stimuli-responsive controlled release nano-delivery systems.

Indexed as

Acrylic ResinsAnti-Infective AgentsBerberineCopperDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsDrug LiberationHydrogen-Ion ConcentrationMicrobial Sensitivity TestsNanoparticlesAcrylic ResinsAnti-Infective AgentsBerberinecarbopol 940CopperDelayed-Action PreparationsDrug CarriersCuS NPsNanocapsulesOne-pot synthesispH responsive controlled releasePolyacrylic acid sodium

Identifiers

PMID40623455
PMCPMC13001173

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.