Evidence map›Paper›PMID 40623052›Full record

ReviewJournal of neurophysiology2025

A comprehensive review of HCN channel expression and I

George Ordiway, Kristine McLellan, Jason Tait Sanchez

Abstract readReview
In one paragraph

Review in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George OrdiwayRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, United States.ORCID 0000-0003-4712-3959
Kristine McLellanRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, United States.ORCID 0000-0003-2963-7278
Jason Tait SanchezRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, United States.ORCID 0000-0003-0115-846X

Funding

Molecular Mechanisms of Tonotopy Development in the Brain StemR01DC017167 · NIDCD · NORTHWESTERN UNIVERSITY · PI SANCHEZ, JASON TAIT · 2019 to 2023
$1.6M
Uncovering the Functional Effects of Neurotrophins in the Auditory BrainstemF31DC021366 · NIDCD · NORTHWESTERN UNIVERSITY · PI Kristine McLellan · 2023 to 2026
$133k
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC017167NIDCD NIH HHS F31 DC021366NIDCD NIH HHS R01 DC017167
6 · The paper itself

Abstract

The hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel is highly specialized, mediating the flow of potassium and sodium ions when a cell is hyperpolarized. Since it was discovered nearly half a century ago, the HCN channel structure and function have been extensively characterized throughout the nervous system. This includes the auditory system, where HCN channels are abundantly expressed and are used to encode sound features with high temporal fidelity. Despite the ubiquitous presence of HCN channels in auditory regions, the physiological benefits of these channels within the auditory system have not been synthesized. Here, we summarize the reported empirical measurements of HCN channel expression and HCN channel-mediated current, known as I

Indexed as

Auditory CortexAuditory PathwaysHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnimalsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsauditoryHCN channelion channelneurophysiologyreview

Identifiers

PMID40623052
PMCPMC12369997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.