ArticlePloS one2025
Association between inflammatory burden index and prognosis in patients with coronary heart disease: A retrospective study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Inflammatory burden index (CRP×NLR) is associated with moderate-to-severe endoscopic activity in hospitalized patients with ulcerative colitis: a single-center retrospective study.Crohn's & colitis 360 · 2026Article
- Inflammation-related composite indices and their association with osteoporosis and fragility fractures in rheumatoid arthritis.Arthritis research & therapy · 2026Article
- Preoperative Inflammatory Burden Index Predicts Atrial Fibrillation After Coronary Artery Bypass Grafting: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Inflammatory Burden Index is Associated with Increased Long-Term Risk of Major Advers Cardiovascular Events in Myocardial Infarction with Non-Obstructive Coronary Arteries.International journal of general medicine · 2026Article
- Associations of cardiometabolic burden with cardiovascular disease-death transitions in metabolic dysfunction-associated steatotic liver disease: a prospective cohort study using multistate analysis.Frontiers in nutrition · 2026Article
- Association of the inflammatory burden index with 1-year major adverse cardiovascular events in patients with HFpEF after myocardial infarction: a single-center retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
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Abstract
backgroundIncreasing evidences indicate that systemic inflammation plays a significant role of adverse prognosis in patients with coronary heart disease (CHD). The inflammatory burden index (IBI) is a novel biomarker that reflects systemic inflammation. The aim of this study was to investigate the association between IBI and prognosis of CHD patients.
methodsIn this retrospective analysis, data from 2453 CHD patients enrolled from December 2017 to December 2022.IBI was defined as neutrophil/lymphocyte*C-reactive protein, with patients categorized into four groups based on quartiles of baseline IBI levels. The primary outcome was adverse cardiovascular and cerebrovascular events (MACCEs) occurring during hospitalization, which included repeat revascularization, new-onset atrial fibrillation (NOAF), stroke, and all-cause in-hospital mortality. Multivariate logistic regression models and restricted cubic spline (RCS) analysis were used to investigate the association between IBI and prognosis of CHD patients.
resultsHigh levels of IBI were associated with higher risk of MACCEs, especially when IBI ≥ 45.68, patients exhibited a higher risk of MACCEs (P < 0.05). After adjusting for baseline confounders, multivariate logistic regression analysis demonstrated that baseline IBI was an independent predictor for NOAF (Odds Ratio (OR): 2.05; 95% confidence interval (CI): 1.30-3.24; P = 0.002) and contrast-induced nephropathy (CIN) (OR: 1.95; 95%CI: 1.16-3.28; P = 0.012) in CHD patients, mainly driven by the highest quartile. In addition, RCS confirmed a linear relationship between IBI and NOAF (P for non-linear = 0.425) and a nonlinear relationship with CIN (P for non-linear = 0.032).
conclusionIBI is a promising biomarker of systemic inflammation in CHD patients, where higher IBI levels are associated with adverse prognosis. These findings may aid clinicians in precise decision-making to improve outcomes in patients with CHD.
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