Evidence map›Paper›PMID 40622848›Full record

ArticleeLife2025

The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast.

Jacob H Cecil, Cristina M Padilla, Austin A Lipinski, Paul Langlais, Xiangxia Luo, Andrew P Capaldi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jacob H CecilDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-1227-8777
Cristina M PadillaDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0009-0000-3330-9782
Austin A LipinskiDepartment of Medicine, University of Arizona, Tucson, United States.
Paul LanglaisDepartment of Medicine, University of Arizona, Tucson, United States.
Xiangxia LuoDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, United States.
Andrew P CapaldiDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, United States.ORCID https://orcid.org/0000-0002-7902-2477

Funding

Dissection of the TORC1 Signaling Network in YeastR01GM097329 · NIGMS · UNIVERSITY OF ARIZONA · PI CAPALDI, ANDREW PAUL · 2011 to 2024
$4.7M
Graduate Training in Biochemistry and Molecular BiologyT32GM136536 · NIGMS · UNIVERSITY OF ARIZONA · PI Andrew Paul Capaldi, FRANS E TAX · 2020 to 2026
$2.4M
Dissection of the TORC1 Signaling Network in YeastR35GM158300 · NIGMS · UNIVERSITY OF ARIZONA · PI Andrew Paul Capaldi · 2025 to 2026
$1.1M
NIGMS NIH HHS R01 GM097329NIGMS NIH HHS R01GM097329NIGMS NIH HHS R35 GM158300NIGMS NIH HHS T32 GM136536NIGMS NIH HHS T32GM136536
6 · The paper itself

Abstract

The Target of Rapamycin kinase Complex 1 (TORC1) regulates cell growth and metabolism in eukaryotes. Previous studies have shown that, in

Indexed as

Carrier ProteinsGene Expression Regulation, FungalMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsSignal TransductionCarrier ProteinsGtr1 protein, S cerevisiaeGTR2 protein, S cerevisiaeMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsTORC1 protein complex, S cerevisiaeTranscription Factorscell biologyGtr1/2nutrientPib2protein kinaseS. cerevisiaeTORC1

Identifiers

PMID40622848
PMCPMC12234008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.