Evidence map›Paper›PMID 40622758›Full record

ArticleAging2025

Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort.

Eleanor Kate Phillips, Yichen Huang, Elizabeth Regan, Barry Make, Matthew Strand, Abebaw Mengistu Yohannes, Nicola A Hanania, Jessica Bon, Karin F Hoth, James D Crapo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eleanor Kate PhillipsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Yichen HuangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Elizabeth ReganDivision of Rheumatology, National Jewish Health, Denver, CO 80206, USA.
Barry MakeDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Matthew StrandDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USA.
Abebaw Mengistu YohannesDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Nicola A HananiaSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Jessica BonSection of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Karin F HothDepartment of Psychiatry, University of Iowa Carver College of Medicine, Lowa City, IA 52242, USA.
James D CrapoDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
COPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2M
Identifying Protein-Protein Network Interactions between COPD Susceptibility GenesR01HL152728 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K, WEI, WENYI · 2021 to 2024
$3.2M
Determinants of Altered Brain Structure and Function in Smokers with COPD-Related Lung PathophysiologyR01HL134822 · NHLBI · UNIVERSITY OF IOWA · PI HOTH, KARIN F · 2017 to 2021
$3.1M
Networks Tools to Understand Sex- and Gender-Specific Drivers of DiseaseR01HG011393 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L, QUACKENBUSH, JOHN · 2021 to 2024
$2.1M
NHGRI NIH HHS R01 HG011393NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01 HL134822NHLBI NIH HHS R01 HL152728NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIEHS NIH HHS HHSN268201600032C
6 · The paper itself

Abstract

Frailty is associated with respiratory exacerbations and mortality in individuals with Chronic Obstructive Pulmonary Disease (COPD). Among those with a smoking history and normal spirometry, frailty's association with respiratory outcomes is less defined. COPDGene is a cohort study of individuals aged 45-80 with a minimum 10 pack-year smoking history. A modified Fried Frailty Phenotype was performed at 10-year follow-up; participants were categorized as frail, prefrail, or robust. Primary outcomes were respiratory exacerbations, epigenetic pace of aging, and all-cause mortality. Among 2665 participants, 401 (15%) were frail and 1352 (51%) were prefrail. Adjusting for smoking and lung function, frailty was associated with prospective respiratory exacerbation rate (IRR 3.4, 95% CI 2.4-4.8), severe exacerbations (OR 2.8(1.8-4.2)), and frequent exacerbations (OR 5.5(3.2-9.3)). Prefrailty was also associated with exacerbation outcomes (rate IRR 1.8(1.4-2.3); severe OR 1.6(1.1-2.2); frequent OR 2.6(1.7-4.1)). Frailty and prefrailty were associated with increased all-cause mortality (AHR: frailty 4.5(2.4-8.5); prefrailty 2.5(1.5-4.2)). All frailty (and most prefrailty) findings persisted in those with normal spirometry. Baseline DunedinPACE of aging was associated with prospective frailty at 10-year follow-up. Frailty associated with respiratory exacerbations and mortality; findings persisted among individuals with normal spirometry, highlighting the relevance of evaluating for frailty in people with a history of smoking.

Indexed as

FrailtyPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overCohort StudiesDisease ProgressionFemaleFrail ElderlyHumansMaleMiddle AgedProspective StudiesSmokingcigarette smokingCOPDepigenetic agingfrailtyrespiratory exacerbations

Identifiers

PMID40622758
PMCPMC12339021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.