Evidence map›Paper›PMID 40622745›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Surviving Extremely Low Birth Weight Infants Have a Higher Risk of ROP in Sub-Saharan Africa.

Tshilidzi van der Lecq, Gerd Holmström, Esmè Jordaan, Gugulabatembunamahlubi Kali, Rudzani Muloiwa, Natasha Rhoda, ROPSA Collaborative Group

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Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tshilidzi van der LecqDepartment of Surgery, Division of Ophthalmology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4712-453X
Gerd HolmströmDepartment of Surgical Sciences, Ophthalmology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-5600-7186
Esmè JordaanBiostatistics Research Unit, South African Medical Research Council, Cape Town, South Africa.
Gugulabatembunamahlubi KaliDivision of Neonatology, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-1426-1207
Rudzani MuloiwaDepartment of Paediatrics & Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Natasha RhodaDepartment of Paediatrics & Child Health, Mowbray Maternity Hospital, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-9194-5522
ROPSA Collaborative Group

Funding

Department of higher education and trainingDiscovery foundationÖgonfonden/Stiftelsen Synfrämjandets ForskningsfondSouth African medical research councilThe Swedish fund
6 · The paper itself

Abstract

aimRetinopathy of prematurity (ROP) risk factors have been investigated in population-based studies from most global regions. No such studies are available from Sub-Saharan Africa (SSA), where improved neonatal care is increasing the survival of preterm infants at risk of ROP.

methodsA population-based study was conducted in infants born in Cape Town, South Africa, from 1 May 2022 to 31 January 2023. The screening criteria were birth weight < 1250 g or gestational age < 32 weeks. The data were extracted from the Retinopathy of Prematurity South African register.

resultsThe study included 378 screened infants, 115 (30.4%) of whom developed ROP. In the multiple regression analyses, lower birth weight was an independent ROP risk factor, OR 1.3 95% CI 1.2-1.5, p < 0.001. Surgical necrotising enterocolitis (NEC) was the only other independent ROP risk factor, OR 5.8 95% CI 1.6-21.0, p = 0.007. Infants with birth weight < 1000 g were 39.4% (130/378) of those screened and more likely to develop ROP compared to larger infants, OR 2.4 95% CI 1.5-3.9, p < 0.001.

conclusionBirth weight remained a significant ROP risk factor, especially for those born weighing less than 1000 g. These infants represented a larger proportion of screened infants compared to previous Sub-Saharan African studies.

Indexed as

Infant, Extremely Low Birth WeightRetinopathy of PrematurityAfrica South of the SaharaFemaleHumansInfant, NewbornMaleRisk FactorsSouth Africaextremely low birth weightpopulation‐basedretinopathy of prematurityROP risk factorssub‐Saharan Africa

Identifiers

PMID40622745
PMCPMC12520265

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