Evidence map›Paper›PMID 40622667›Full record

ArticleEpilepsia2025

Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome.

Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Limei ZhuDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Yiannos DemetriouDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Joseph BardenDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Juan DislaDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Meiling ZhaoDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Joanna MattisDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-0341-1270

Funding

Cortico-hippocampal circuit dysfunction in an Scn1a mouse model of epilepsyK08NS121464 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MATTIS, JOANNA H · 2021 to 2025
$969k
Kenneth Eisenberg Taubman Emerging Scholar AwardNINDS NIH HHS K08 NS121464
6 · The paper itself

Abstract

objectiveDravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage-gated sodium channel Na

methodsIn this study, we employed whole cell patch clamp recordings in acute brain slices to characterize the electrophysiological properties of MS neurons in Scn1a

resultsWe found no discernible genotype-related differences in MS cholinergic neurons, but significant dysfunction within MS parvalbumin-expressing (PV) inhibitory neurons in Scn1a SIGNIFICANCE: These results confirm that the MS is an additional locus of pathology in DS and may contribute to comorbidities such as cognitive impairment.

Indexed as

Epilepsies, MyoclonicNeuronsParvalbuminsSeptal NucleiAnimalsDisease Models, AnimalFemaleInterneuronsMaleMiceMice, Inbred C57BLMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesNAV1.1 Voltage-Gated Sodium ChannelParvalbuminsScn1a protein, mouseacetylcholineepilepsyinhibition

Identifiers

PMID40622667
PMCPMC12258622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.