Evidence map›Paper›PMID 40622650›Full record

ArticleEJNMMI research2025

Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand

Scott A Norris, Noah L Goldman, Mahdjoub Hamdi, Stephen M Moerlein, Richard Laforest, Morvarid Karimi, Joel S Perlmutter, Zhude Tu

Abstract read
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. First-in-human PET study of [Journal of translational medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott A NorrisDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Ave, CB 8111, St. Louis, MO, 63110, USA. norriss@wustl.edu.ORCID http://orcid.org/0000-0002-3835-0976
Noah L GoldmanDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Ave, CB 8111, St. Louis, MO, 63110, USA.
Mahdjoub HamdiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Stephen M MoerleinMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Richard LaforestMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Morvarid KarimiDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Ave, CB 8111, St. Louis, MO, 63110, USA.
Joel S PerlmutterDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Ave, CB 8111, St. Louis, MO, 63110, USA.
Zhude TuMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
NIH HHS NS075321NIH HHS NS075527NIH HHS NS103988NIH HHS NS116025NIH HHS NS124789NIH HHS NS134586NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS124789NINDS NIH HHS R01 NS134586NINDS NIH HHS RF1 NS075321NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

backgroundThe vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone (

resultsThere were no adverse events after

conclusionsHuman bio-distribution data showed high retention of

Indexed as

PETRadiation dosimetryVAChTVesicular acetylcholine transporter

Identifiers

PMID40622650
PMCPMC12234429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.