Evidence map›Paper›PMID 40622619›Full record

ArticleActa parasitologica2025

In Vitro Anti-Leishmanial Activity and Molecular Docking of Eugenol as a Potential Agent Against Leishmania Major.

Neda Mohamadi, Shiva Karimi, Fariba Sharififar, Ehsan Salarkia, Fatemeh Sharifi

Abstract read
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In one paragraph

Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neda MohamadiHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Shiva KarimiHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Fariba SharififarHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Ehsan SalarkiaLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Fatemeh SharifiResearch Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran. fatemeh7267@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEugenol is an aromatic compound that belongs to the phenol group found in various natural sources, such as clove oil. This study aimed to investigate eugenol's leishmanicidal activity and its mechanism of action using molecular docking to predict potential biochemical targets of eugenol in Leishmania major.

methodsThe interaction between eugenol and TNF-α/IL-12p40 was evaluated using docking methods. The leishmanicidal activities of eugenol, MA (Glucantime

resultsIC

conclusionThe superior efficacy of the combined treatment of eugenol and MA on L. major necessitates further research on the clinical potential of this combination in the treatment of leishmaniasis.

Indexed as

Antiprotozoal AgentsEugenolLeishmania majorAnimalsCytokinesInhibitory Concentration 50Interleukin-12 Subunit p40MacrophagesMiceMolecular Docking SimulationTumor Necrosis Factor-alphaAntiprotozoal AgentsCytokinesEugenolInterleukin-12 Subunit p40Tumor Necrosis Factor-alphaAnti-Leishmania majorCombination therapyCytokines gene expressionEugenolMolecular docking

Identifiers

PMID40622619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.