Evidence map›Paper›PMID 40622576›Full record

ReviewPediatric nephrology (Berlin, Germany)2026

Nephrotoxicity of immunotherapy and targeted therapies used to treat paediatric cancer.

Megan B Sim, Shahrad Rod Rassekh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Megan B SimDepartment of Paediatrics, Division of Paediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, Canada.
Shahrad Rod RassekhDepartment of Paediatrics, Division of Paediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, Canada. rrassekh@cw.bc.ca.ORCID http://orcid.org/0000-0001-8005-2641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with cancer have had significant improvements in cure rates over the last few decades through advancements in surgery, chemotherapy, and radiation therapy. However, survivors have been left with long-term adverse effects of therapy, including significant nephrotoxicity. With advancement in genomic sequencing and novel therapeutics, there has been a recent shift towards the incorporation of targeted therapies and immunotherapy to improve cure rates and reduce long-term sequelae in survivors. However, these new therapies are not without their own toxicities, and with more widespread use of these agents, paediatric oncologists and nephrologists need to be aware of the short- and long-term impact of these treatments on children with cancer. This review highlights some of the emerging knowledge regarding the impact of these novel therapeutics on the kidneys.

Indexed as

Antineoplastic AgentsImmunotherapyKidneyMolecular Targeted TherapyNeoplasmsChildHumansAntineoplastic AgentsAdverse effectsImmunotherapyKidney toxicityNephrotoxicityPediatric cancerTargeted therapy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.