Evidence map›Paper›PMID 40622557›Full record

ReviewNatural products and bioprospecting2025

Unlocking potent anti-tuberculosis natural products through structure-activity relationship analysis.

Delfly Booby Abdjul, Fitri Budiyanto, Joko Tri Wibowo, Tutik Murniasih, Siti Irma Rahmawati, Dwi Wahyu Indriani, Masteria Yunovilsa Putra, Asep Bayu

Abstract readReview
In one paragraph

Review in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Delfly Booby AbdjulResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia. booby_abdjul@yahoo.com.
Fitri BudiyantoResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Joko Tri WibowoResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Tutik MurniasihResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Siti Irma RahmawatiResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Dwi Wahyu IndrianiResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Masteria Yunovilsa PutraResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia.
Asep BayuResearch Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta Bogor KM.46, Cibinong, Bogor, West Java, 16911, Indonesia. asep044@brin.go.id.ORCID http://orcid.org/0000-0002-5693-0501

Funding

Kementerian Keuangan Republik Indonesia RIIM Competition batch 3 program
6 · The paper itself

Abstract

Tuberculosis (TB) remains a world health problem due to the high number of affected individuals, high mortality rates, prolonged treatment durations, and the increasing prevalence of resistance to commercial TB drugs. The emergence of resistance to anti-TB drugs has necessitated urgent research into drug discovery and development, focusing on novel mechanisms of action against Mycobacterium tuberculosis resistant strains. Natural products, with their remarkable structural diversity and bioactivity, are promising sources for the development of new TB drugs or the identification of potential chemical scaffolds exhibiting potent and novel biological activity with minimal or no cytotoxicity to host cells. This review focuses on potent anti-TB natural products with minimum inhibitory concentration (MIC) values below 5 µg mL

Indexed as

Anti-TB scaffoldNatural ProductsStructure–activity relationshipTuberculosis

Identifiers

PMID40622557
PMCPMC12234934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.