Evidence map›Paper›PMID 40622551›Full record

ReviewAdvances in experimental medicine and biology2025

Innate Immune Mechanisms in the Central Nervous System.

Abhishek Shastri, Hadida Yasmin, Uday Kishore

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abhishek ShastriCentral and North West London NHS Foundation Trust, London, UK. abhishek.shastri@nhs.net.
Hadida YasminCooch Behar Panchanan Barma University, Cooch Behar, West Bengal, India.
Uday KishoreDepartment of Veterinary Medicine, U.A.E University, Al Ain, UAE.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central nervous system (CNS) is a complex network of cells involved in highly vital functions such as sensation, movement, ability to think and plan, consolidation of impulses from sense organs, awareness, and involuntary functions to name a few. Over the course of time, the concept that the brain and spinal cord were 'immune-privileged' has gradually changed, and it is now well-known that the CNS not only interacts with peripheral immune cells but is also capable of harbouring immune cells. This chapter covers key components of innate immunity as part of the CNS, including the blood-brain barrier and its role in maintaining homeostasis and being an interface in interaction with peripheral immune system. We also discuss about various innate immune cells including microglia, the resident macrophages that are very crucial for the CNS pathophysiology. The chapter also details mechanisms of neuroinflammation via various pattern-recognition receptors including the complement system, and the pathophysiological role the innate immunity plays in neurodegenerative diseases.

Indexed as

Central Nervous SystemImmunity, InnateNeurodegenerative DiseasesAnimalsBlood-Brain BarrierBrainComplement System ProteinsHumansMacrophagesMicrogliaNeuroinflammatory DiseasesComplement System ProteinsBlood-brain barrierComplement systemInnate immunityMicrogliaNeuroinflammation

Identifiers

PMID40622551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.