Evidence map›Paper›PMID 40622525›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2025

E. coli Meningitis.

Vishwanath Venketaraman, Karim Hajjar, Nisar Sheren

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vishwanath VenketaramanCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA. vvenketaraman@westernu.edu.
Karim HajjarCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
Nisar SherenCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.

Funding

Glutathione depletion in the CNS and its effects on Mtb infectionR15HL143545 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI VENKETARAMAN, VISHWANATH · 2019 to 2024
$852k
NHLBI NIH HHS R15 HL143545
6 · The paper itself

Abstract

Escherichia coli (E. coli) is a gram-negative organism that commonly colonizes the gastrointestinal tract and has the ability to travel hematogenously to the central nervous system, resulting in inflammation of the brain and spinal cord membranes. E. coli meningitis is a significant cause of mortality and morbidity in neonates and infants throughout the world and is less common in adults. E. coli meningitis has a high degree of bacteremia and invasion of the blood-brain barrier with specific microbial and host factors as well as microbe- and host specific signaling molecules. The blocking of microbial and host factors that contribute to E. coli invasion of the blood-brain barrier is shown to be efficient in preventing E. coli penetration into the brain. It is critical to outline current in vitro and in vivo models to understand the pathogenesis of E. coli meningitis and to further refine diagnostic workup and treatment plans.

Indexed as

Escherichia coliMeningitis, Escherichia coliAnimalsBlood-Brain BarrierDisease Models, AnimalHost-Pathogen InteractionsHumansBlood-brain barrierCNF1Escherichia coli meningitisFimHIn vitroIn vivoOmpA

Identifiers

PMID40622525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.