ArticleObesity surgery2025
Comparative Analysis of the Incidence of Post-bariatric Cholelithiasis in Sleeve Gastrectomy and Roux-en-Y Gastric Bypass.
Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Surgeons and Experts' Perspectives in Concomitant Bariatric Surgery with Cholecystectomy: Bari-Chole Egypt Survey.Obesity surgery · 2026Article
- Optimal Timing of GLP-1 Receptor Agonist Initiation in Patients with Obesity Eligible for Metabolic Bariatric Surgery.Obesity surgery · 2026Article
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5 authors.
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Abstract
backgroundMetabolic bariatric surgery is an effective treatment for severe obesity, yet it may increase the risk of developing cholelithiasis. Understanding risk factors for gallstone formation is crucial to optimize postoperative care.
objectiveTo compare the incidence and associated factors of post-bariatric cholelithiasis between patients undergoing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB).
methodsA retrospective cohort study was conducted on 565 patients who underwent SG or RYGB by a single surgeon between 2021 and 2025. Patients were followed for at least 2 years with biannual ultrasound assessments. Those with preoperative cholelithiasis or incomplete follow-up were excluded. Data on demographics, associated medical problems, weight loss, and surgical details were analyzed using chi-square and unpaired Student's t-test. The Mann-Whitney test was also used because no normal distribution was found. The significance level adopted was 5% in all hypothesis tests. A logistic regression was also performed in order to identify the factors that jointly determine cholelithiasis. The values of the model coefficients and the respective Odds Ratio with a 95% confidence interval were also provided.
resultsThe overall incidence of cholelithiasis was 13.8%, with a higher frequency in females (85.9%, p < 0.0001) and with no statistical difference between both procedures (p = 0.1405) regarding incidence, although it is slightly higher in the RYGB group. However, mean time to diagnosis was significantly shorter in RYGB compared to SG (7.7 ± 5.8 vs. 11.5 ± 9.1 months, p = 0.0211), despite no significant differences in TWL% or EWL%. There is a tendency towards a higher prevalence of cholelithiasis in women (p = 0.0842). There was a higher incidence of cholelithiasis in white people (55.13%; p < 0.0001). The presence of steatosis was significantly associated with gallstone formation (p = 0.0265).
conclusionPost-bariatric cholelithiasis develops earlier after RYGB than SG. Female sex and MASLD are significant risk factors. These findings emphasize the need for targeted surveillance and consideration of prophylactic strategies in high-risk patients.
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