Evidence map›Paper›PMID 40622437›Full record

ReviewCurrent medical science2025

The Role of the Subnucleus Reticularis Dorsalis (SRD) in Pain Modulation: A Literature Review.

Zi-Yan Zhang, Jia-le Mei, Yi-Qing Rao, Ke-Xing Wan, Jia-Jia Huang, Ling-Ling Yu, Xiang-Hong Jing, Man Li, Zheng-Tao Lv

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The ENKCNS neuroscience & therapeutics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zi-Yan Zhang *Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jia-le Mei *Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yi-Qing RaoHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ke-Xing WanHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Jia-Jia HuangHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ling-Ling YuHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xiang-Hong JingInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100010, China. jxhtjb@263.net.
Man LiHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. liman73@mails.tjmu.edu.cn.ORCID http://orcid.org/0000-0003-4041-0437
Zheng-Tao LvDepartment of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. zheng-tao_lyu@tjh.tjmu.edu.cn.

Funding

Key Program of the National Natural Science Foundation of China (No.82130122). 2950000RMB
6 · The paper itself

Abstract

The subnucleus reticularis dorsalis (SRD), also known as the dorsal reticular nucleus (DRt) or dorsal medullary reticular nucleus (MdD), which resides at the caudal end of the medulla, plays a pivotal role in regulating pain perception. Despite extensive research efforts to unravel its mechanisms, the operational intricacies of SRD remain poorly understood. Advances in experimental methodologies such as brain imaging and chemogenetics have facilitated deeper investigations into the involvement of SRD in various pain disorders. This comprehensive review aims to analyze 36 years (1989-2024) of preclinical research highlighting the critical role of SRD in diffuse noxious inhibitory control (DNIC), also known as conditioned pain modulation (CPM) in humans, and its interconnected neural circuits. Moreover, this review explores the neural circuits related to SRD, including locus coeruleus (LC)-SRD, parabrachial nucleus (PBN)-SRD, rostroventromedial medulla (RVM)-ventrolateral medulla (VLM)-SRD, anterior cingulate cortex (ACC)-SRD, medial medullary reticular formation (mMRF)-SRD, and dorsal striatum (DS)-SRD. Their activation also plays a significant role in analgesia. The pivotal roles of neurotransmitters such as μ-opioid receptor (MOR), noradrenaline, and metabotropic glutamate receptor 7 (mGluR7) in modulating SRD responsiveness to pain stimuli are also discussed, as are the influences of SRD on different pain types. This review identified promising avenues for innovative analgesic treatments by shedding light on potential therapeutic strategies targeting SRD.

Indexed as

Medulla OblongataPainReticular FormationAnimalsHumansPain ManagementDescending modulation pathwaysDNICNeural circuitsNeurotransmittersPain modulationSRD

Identifiers

PMID40622437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.