Evidence map›Paper›PMID 40622256›Full record

ArticleeLife2025

Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma.

M Reza Bahranifard, Jessica Chan, A Thomas Read, Guorong Li, Lin Cheng, Babak N Safa, Seyed Mohammad Siadat, Anamik Jhunjhunwala, Hans E Grossniklaus, Stanislav Y Emelianov and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Absence of Glaucoma in Tg-MYOCY437H Mice of Diverse Genetic Backgrounds.Investigative ophthalmology & visual science · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

M Reza BahranifardWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, United States.ORCID https://orcid.org/0009-0005-1369-8772
Jessica ChanSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, United States.
A Thomas ReadWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States.ORCID https://orcid.org/0000-0002-2764-6413
Guorong LiDepartment of Ophthalmology, Duke University, Durham, United States.ORCID https://orcid.org/0009-0002-4047-8546
Lin ChengDepartment of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, United States.
Babak N SafaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States.ORCID https://orcid.org/0000-0002-1849-2870
Seyed Mohammad SiadatWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States.ORCID https://orcid.org/0000-0002-5063-0305
Anamik JhunjhunwalaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States.ORCID https://orcid.org/0000-0002-7126-4463
Hans E GrossniklausDepartments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, United States.
Stanislav Y EmelianovWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States.
W Daniel StamerDepartment of Ophthalmology, Duke University, Durham, United States.ORCID https://orcid.org/0000-0002-2504-8997
Markus H KuehnDepartment of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, United States.
C Ross EthierWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, United States.ORCID https://orcid.org/0000-0001-6110-3052

Funding

Magnetic Steering and Longitudinal Visualization of Stem Cells for Trabecular Meshwork Therapy in GlaucomaR01EY030071 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI EMELIANOV, STANISLAV Y, ETHIER, C ROSS · 2019 to 2022
$2.3M
Georgia Research Alliance Endowed chairNEI NIH HHS R01 EY030071NIH HHS R01 EY030071RRD VA I01 RX005008
6 · The paper itself

Abstract

Trabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excellent efficiency and tissue-specific targeting, we delivered two types of cells into a mouse model of glaucoma: either human adipose-derived mesenchymal stem cells (hAMSCs) or induced pluripotent cell derivatives (iPSC-TM cells). We observed a 4.5 [3.1, 6.0] mmHg or 27% reduction in intraocular pressure (IOP) for 9 months after a single dose of only 1500 magnetically steered hAMSCs, explained by increased outflow through the conventional pathway and associated with a higher TM cellularity. iPSC-TM cells were also effective, but less so, showing only a 1.9 [0.4, 3.3] mmHg or 13% IOP reduction and increased risk of tumorigenicity. In both cases, injected cells remained detectable in the iridocorneal angle 3 weeks post-transplantation. Based on the locations of the delivered cells, the mechanism of IOP lowering is most likely paracrine signaling. We conclude that magnetically steered hAMSC cell therapy has potential for long-term treatment of ocular hypertension in glaucoma.

Indexed as

Cell- and Tissue-Based TherapyGlaucoma, Open-AngleIntraocular PressureMesenchymal Stem Cell TransplantationAnimalsDisease Models, AnimalHumansInduced Pluripotent Stem CellsMesenchymal Stem CellsMiceTrabecular Meshworkglaucomaintraocular pressuremedicinemouseregenerative medicinestem cellstem cells

Identifiers

PMID40622256
PMCPMC12234007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.