Observational studyInvestigative ophthalmology & visual science2025
Natural Course and Risk Factors of Glaucoma Development in the Untreated Fellow Eye in Unilateral Normal-Tension Glaucoma.
Observational study in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Inter-eye comparison of corneal stiffness parameters in primary open-angle glaucoma patients with unilateral damage.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Molecular and Histological Characterization of a Novel Hydrogel-Based Strategy for Inducing Experimental Glaucoma in Mice.International journal of molecular sciences · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To test whether the level of intraocular pressure (IOP) significantly affects the development of glaucoma in the untreated fellow eye of patients with unilateral normal-tension glaucoma (NTG). Methods: Long-term observational study on consecutive patients newly diagnosed with unilateral NTG and followed up for >5 years with more than five IOP measurements. We investigated the factors associated with NTG development in the untreated fellow eye, including the longitudinal IOP profile. Results: A total of 194 patients with a baseline age of 50.5 ± 12.1 years were followed up for 8.4 ± 1.6 years. NTG development in the untreated fellow eye occurred in 48 patients (24.7%), with a mean interval of 5.2 ± 2.1 years. Patients with fellow eye NTG development had significantly higher baseline untreated IOP in both eyes and higher follow-up IOPs in the fellow eye compared to those who did not (all P < 0.05). Kaplan-Meier survival analysis and multivariate Cox regression analysis revealed that an average follow-up IOP ≥14 mm Hg in the fellow eye was associated with a significantly increased risk of glaucoma development compared to those with IOP <14 mm Hg (hazard ratio, 3.626; 95% confidence interval, 1.519-8.654; P = 0.004), particularly for the eyes with baseline IOP ≥14 mm Hg. Conclusions: In this 8-year cohort, we observed NTG development in the untreated fellow eyes in 24.7% of the patients with unilateral NTG. The untreated average follow-up IOP was significantly associated with NTG development, with an average IOP ≥14 mm Hg exhibiting a threefold increased risk.
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