ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2026
Prior procedures, graft location, preoperative physical health, postoperative strength and graft integrity are associated with 10-year clinical outcome after matrix-induced autologous chondrocyte implantation.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Prior procedures, graft location, preoperative physical health, postoperative strength and graft integrity are associated with 10-year clinical outcome after matrix-induced autologous chondrocyte implantation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Effects of a Novel Mammalian-Derived Collagen Matrix on Human Articular Cartilage-Derived Chondrocytes from Osteoarthritis Patients.International journal of molecular sciences · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
purposeTo investigate factors associated with 10-year clinical scores after matrix-induced autologous chondrocyte implantation (MACI).
methodsThis retrospective case series included 143 MACI patients with 10-year clinical and radiological follow-up. Clinical assessment included the Knee Injury and Osteoarthritis Outcome Score (KOOS) quality of life (KOOS-QOL) and sport and recreation (KOOS-Sport/Rec) subscales, and patient satisfaction. Regression analysis investigated the contribution of patient (age, sex, body mass index and preoperative physical health), surgical (symptom duration, prior surgeries, defect size and location) and postoperative variables, such as knee extensor strength and a magnetic resonance imaging (MRI) composite graft score, to 10-year clinical scores and being 'very satisfied'.
resultsThe KOOS-QOL (p < 0.001) and KOOS-Sport/Rec (p < 0.0001) improved from baseline to 10 years, with 88 (61.5%) patients 'very satisfied' with their outcome. A lower number of prior surgical procedures, greater knee extensor strength, and a better 10-year MRI score contributed significantly to a higher KOOS-QOL. For the KOOS-Sport/Rec, a lower number of prior surgical procedures, undergoing tibiofemoral (versus patellofemoral) MACI, greater preoperative physical health and a better 10-year MRI score contributed significantly to a better score. Finally, a lower number of prior procedures and greater preoperative physical health contributed to a patient being 'very satisfied'.
conclusionFactors including the number of prior procedures, defect location, preoperative physical health, postoperative quadriceps strength and MRI-based graft integrity were associated with improved 10-year clinical scores. This information will permit more tailored patient discussion, along with the setting of realistic, longer-term expectations for outcomes. LEVEL OF EVIDENCE: Level IV.
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